Sensing Conductive Hydrogels for Rapid Detection of Cytokines in Blood

Dong Sik Shin, Zimple Matharu, Jungmok You, Christian Siltanen, Tam Vu, Vijay Krishna Raghunathan, Gulnaz Stybayeva, Ashley E Hill, Alexander Revzin

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Conducting polymer hydrogel is fabricated atop gold or ITO electrodes and is functionalized with monoclonal antibodies. Binding of interferon-γ molecules causes redox properties of conductive hydrogel to change in a concentration-dependent fashion without the need for washing or sample handling steps. This conductive hydrogel remains functional in a fouling media such as whole blood.

Original languageEnglish (US)
Pages (from-to)659-664
Number of pages6
JournalAdvanced healthcare materials
Volume5
Issue number6
DOIs
StatePublished - Mar 23 2016

Keywords

  • Biosensors
  • Conducting polymer hydrogels
  • Cytokine detection
  • Electrochemical detection
  • Immunoassays

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

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    Shin, D. S., Matharu, Z., You, J., Siltanen, C., Vu, T., Raghunathan, V. K., Stybayeva, G., Hill, A. E., & Revzin, A. (2016). Sensing Conductive Hydrogels for Rapid Detection of Cytokines in Blood. Advanced healthcare materials, 5(6), 659-664. https://doi.org/10.1002/adhm.201500571