Sendai viral pneumonia in aged BALB/c mice

Robert O. Jacoby, Pravin N. Bhatt, Stephen W Barthold, David G. Brownstein

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Sendai virus (SV) infection in aged BALB/c mice was evaluated as a natural model for age-associated susceptibility to viral pneumonia. Young (2 month-old) and aged (22-24 month-old) BALB/c mice were inoculated intranasally with 100 median pneumonia doses (PD50) of SV and examined at 6, 10, and 20 days by virus titration, immunohistochemistry, histopathology, and serology. The aged mice had significantly higher virus titers in lung, prolonged infection, delayed development, and resolution of pneumonia and significantly lower serum antibody titers. In a second experiment, the responses of young mice were compared to intermediate-aged mice (11-13 and 17-18 months old). The intermediate-aged mice had some characteristics of young mice and others of aged mice. The results indicate that SV infection can be used to study aging-associated susceptibility to a pneumotropic virus in a natural host, and that susceptibility of mice to viral pneumonia increases gradually during aging.

Original languageEnglish (US)
Pages (from-to)89-100
Number of pages12
JournalExperimental Gerontology
Volume29
Issue number1
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • aged mice
  • model
  • pathology
  • pneumonia
  • sendai virus
  • virology

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

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