Sendai viral pneumonia in aged BALB/c mice

Robert O. Jacoby; Pravin N. Bhatt; Stephen W Barthold; David G. Brownstein

doi:10.1016/0531-5565(94)90065-5

Sendai viral pneumonia in aged BALB/c mice

Robert O. Jacoby, Pravin N. Bhatt, Stephen W Barthold, David G. Brownstein

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Sendai virus (SV) infection in aged BALB/c mice was evaluated as a natural model for age-associated susceptibility to viral pneumonia. Young (2 month-old) and aged (22-24 month-old) BALB/c mice were inoculated intranasally with 100 median pneumonia doses (PD₅₀) of SV and examined at 6, 10, and 20 days by virus titration, immunohistochemistry, histopathology, and serology. The aged mice had significantly higher virus titers in lung, prolonged infection, delayed development, and resolution of pneumonia and significantly lower serum antibody titers. In a second experiment, the responses of young mice were compared to intermediate-aged mice (11-13 and 17-18 months old). The intermediate-aged mice had some characteristics of young mice and others of aged mice. The results indicate that SV infection can be used to study aging-associated susceptibility to a pneumotropic virus in a natural host, and that susceptibility of mice to viral pneumonia increases gradually during aging.

Original language	English (US)
Pages (from-to)	89-100
Number of pages	12
Journal	Experimental Gerontology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/0531-5565(94)90065-5
State	Published - 1994
Externally published	Yes

Keywords

aged mice
model
pathology
pneumonia
sendai virus
virology

ASJC Scopus subject areas

Aging
Medicine(all)

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title = "Sendai viral pneumonia in aged BALB/c mice",

abstract = "Sendai virus (SV) infection in aged BALB/c mice was evaluated as a natural model for age-associated susceptibility to viral pneumonia. Young (2 month-old) and aged (22-24 month-old) BALB/c mice were inoculated intranasally with 100 median pneumonia doses (PD50) of SV and examined at 6, 10, and 20 days by virus titration, immunohistochemistry, histopathology, and serology. The aged mice had significantly higher virus titers in lung, prolonged infection, delayed development, and resolution of pneumonia and significantly lower serum antibody titers. In a second experiment, the responses of young mice were compared to intermediate-aged mice (11-13 and 17-18 months old). The intermediate-aged mice had some characteristics of young mice and others of aged mice. The results indicate that SV infection can be used to study aging-associated susceptibility to a pneumotropic virus in a natural host, and that susceptibility of mice to viral pneumonia increases gradually during aging.",

keywords = "aged mice, model, pathology, pneumonia, sendai virus, virology",

author = "Jacoby, {Robert O.} and Bhatt, {Pravin N.} and Barthold, {Stephen W} and Brownstein, {David G.}",

year = "1994",

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T1 - Sendai viral pneumonia in aged BALB/c mice

AU - Jacoby, Robert O.

AU - Bhatt, Pravin N.

AU - Barthold, Stephen W

AU - Brownstein, David G.

PY - 1994

Y1 - 1994

N2 - Sendai virus (SV) infection in aged BALB/c mice was evaluated as a natural model for age-associated susceptibility to viral pneumonia. Young (2 month-old) and aged (22-24 month-old) BALB/c mice were inoculated intranasally with 100 median pneumonia doses (PD50) of SV and examined at 6, 10, and 20 days by virus titration, immunohistochemistry, histopathology, and serology. The aged mice had significantly higher virus titers in lung, prolonged infection, delayed development, and resolution of pneumonia and significantly lower serum antibody titers. In a second experiment, the responses of young mice were compared to intermediate-aged mice (11-13 and 17-18 months old). The intermediate-aged mice had some characteristics of young mice and others of aged mice. The results indicate that SV infection can be used to study aging-associated susceptibility to a pneumotropic virus in a natural host, and that susceptibility of mice to viral pneumonia increases gradually during aging.

AB - Sendai virus (SV) infection in aged BALB/c mice was evaluated as a natural model for age-associated susceptibility to viral pneumonia. Young (2 month-old) and aged (22-24 month-old) BALB/c mice were inoculated intranasally with 100 median pneumonia doses (PD50) of SV and examined at 6, 10, and 20 days by virus titration, immunohistochemistry, histopathology, and serology. The aged mice had significantly higher virus titers in lung, prolonged infection, delayed development, and resolution of pneumonia and significantly lower serum antibody titers. In a second experiment, the responses of young mice were compared to intermediate-aged mice (11-13 and 17-18 months old). The intermediate-aged mice had some characteristics of young mice and others of aged mice. The results indicate that SV infection can be used to study aging-associated susceptibility to a pneumotropic virus in a natural host, and that susceptibility of mice to viral pneumonia increases gradually during aging.

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