The effect of seminal plasma, epididymal spermatozoa, or whole semen on antibody producing cells was examined in vitro after (i) direct culture with spleen or B cells, and (ii) cocultivation of B cells with T cells previously incubated with seminal plasma. Seminal plasma, and not epididymal spermatozoa, have an inhibitory effect on the direct hemolytic plague forming cell response. This was mediated by a direct inhibitory effect on the B cell and not through the generation of suppressor T cells as demonstrated by responses to T-independent and dependent antigens. Thus, the mode of suppressive action of seminal plasma in vitro is probably different from that previously reported in vitro.
|Original language||English (US)|
|Number of pages||6|
|State||Published - 1984|
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