Seminal plasma inhibits lymphocyte response to T-dependent and independent antigens in vitro

I. K. Thomas, Kent L Erickson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The effect of seminal plasma, epididymal spermatozoa, or whole semen on antibody producing cells was examined in vitro after (i) direct culture with spleen or B cells, and (ii) cocultivation of B cells with T cells previously incubated with seminal plasma. Seminal plasma, and not epididymal spermatozoa, have an inhibitory effect on the direct hemolytic plague forming cell response. This was mediated by a direct inhibitory effect on the B cell and not through the generation of suppressor T cells as demonstrated by responses to T-independent and dependent antigens. Thus, the mode of suppressive action of seminal plasma in vitro is probably different from that previously reported in vitro.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalImmunology
Volume52
Issue number4
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology

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