Seminal plasma inhibits lymphocyte response to T-dependent and independent antigens in vitro

I. K. Thomas, Kent L Erickson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The effect of seminal plasma, epididymal spermatozoa, or whole semen on antibody producing cells was examined in vitro after (i) direct culture with spleen or B cells, and (ii) cocultivation of B cells with T cells previously incubated with seminal plasma. Seminal plasma, and not epididymal spermatozoa, have an inhibitory effect on the direct hemolytic plague forming cell response. This was mediated by a direct inhibitory effect on the B cell and not through the generation of suppressor T cells as demonstrated by responses to T-independent and dependent antigens. Thus, the mode of suppressive action of seminal plasma in vitro is probably different from that previously reported in vitro.

Original languageEnglish (US)
Pages (from-to)721-726
Number of pages6
JournalImmunology
Volume52
Issue number4
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology

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