Semantic processes leading to true and false memory formation in schizophrenia

Pedro M. Paz-Alonso, Simona Ghetti, Ian Ramsay, Marjorie Solomon Friedman, Jong Yoon, Cameron S Carter, John D Ragland

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits is not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under "standard" instructions and the other half under explicit "relational processing" instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit "relational processing" instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients' semantic lexicon.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalSchizophrenia Research
Volume147
Issue number2-3
DOIs
StatePublished - Jul 2013

Fingerprint

Semantics
Schizophrenia
Episodic Memory

Keywords

  • Episodic memory
  • Memory encoding
  • Relational processing
  • Semantic processing

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Semantic processes leading to true and false memory formation in schizophrenia. / Paz-Alonso, Pedro M.; Ghetti, Simona; Ramsay, Ian; Friedman, Marjorie Solomon; Yoon, Jong; Carter, Cameron S; Ragland, John D.

In: Schizophrenia Research, Vol. 147, No. 2-3, 07.2013, p. 320-325.

Research output: Contribution to journalArticle

Paz-Alonso, Pedro M. ; Ghetti, Simona ; Ramsay, Ian ; Friedman, Marjorie Solomon ; Yoon, Jong ; Carter, Cameron S ; Ragland, John D. / Semantic processes leading to true and false memory formation in schizophrenia. In: Schizophrenia Research. 2013 ; Vol. 147, No. 2-3. pp. 320-325.
@article{54342a85430a474f94f976a292cf9768,
title = "Semantic processes leading to true and false memory formation in schizophrenia",
abstract = "Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits is not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under {"}standard{"} instructions and the other half under explicit {"}relational processing{"} instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit {"}relational processing{"} instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients' semantic lexicon.",
keywords = "Episodic memory, Memory encoding, Relational processing, Semantic processing",
author = "Paz-Alonso, {Pedro M.} and Simona Ghetti and Ian Ramsay and Friedman, {Marjorie Solomon} and Jong Yoon and Carter, {Cameron S} and Ragland, {John D}",
year = "2013",
month = "7",
doi = "10.1016/j.schres.2013.04.007",
language = "English (US)",
volume = "147",
pages = "320--325",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Semantic processes leading to true and false memory formation in schizophrenia

AU - Paz-Alonso, Pedro M.

AU - Ghetti, Simona

AU - Ramsay, Ian

AU - Friedman, Marjorie Solomon

AU - Yoon, Jong

AU - Carter, Cameron S

AU - Ragland, John D

PY - 2013/7

Y1 - 2013/7

N2 - Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits is not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under "standard" instructions and the other half under explicit "relational processing" instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit "relational processing" instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients' semantic lexicon.

AB - Encoding semantic relationships between items on word lists (semantic processing) enhances true memories, but also increases memory distortions. Episodic memory impairments in schizophrenia (SZ) are strongly driven by failures to process semantic relations, but the exact nature of these relational semantic processing deficits is not well understood. Here, we used a false memory paradigm to investigate the impact of implicit and explicit semantic processing manipulations on episodic memory in SZ. Thirty SZ and 30 demographically matched healthy controls (HC) studied Deese/Roediger-McDermott (DRM) lists of semantically associated words. Half of the lists had strong implicit semantic associations and the remainder had low strength associations. Similarly, half of the lists were presented under "standard" instructions and the other half under explicit "relational processing" instructions. After study, participants performed recall and old/new recognition tests composed of targets, critical lures, and unrelated lures. HC exhibited higher true memories and better discriminability between true and false memory compared to SZ. High, versus low, associative strength increased false memory rates in both groups. However, explicit "relational processing" instructions positively improved true memory rates only in HC. Finally, true and false memory rates were associated with severity of disorganized and negative symptoms in SZ. These results suggest that reduced processing of semantic relationships during encoding in SZ may stem from an inability to implement explicit relational processing strategies rather than a fundamental deficit in the implicit activation and retrieval of word meanings from patients' semantic lexicon.

KW - Episodic memory

KW - Memory encoding

KW - Relational processing

KW - Semantic processing

UR - http://www.scopus.com/inward/record.url?scp=84878997804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878997804&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2013.04.007

DO - 10.1016/j.schres.2013.04.007

M3 - Article

C2 - 23623175

AN - SCOPUS:84878997804

VL - 147

SP - 320

EP - 325

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 2-3

ER -