Self-selection and the obese Zucker rat: The effect of dietary fat dilution

Thomas W. Castonguay, Sheri L. Burdick, Maria A. Guzman, George H. Collier, Judith S. Stern

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Adult female lean and obese Zucker rats were allowed to compose their own diets by giving them access to three macronutrient sources. After a baseline period, the fat source was serially diluted. In all, eight concentrations of fat were used. Dilution of the fat source promoted significant increases in the intake of fat by both lean and obese rats. The increased intake of fat was not simply compensatory in nature, but rather represented significant increases in fat consumption. These results suggest that the reported increased appetite for fat of the obese rat is not a unique trait of that genotype. Further, results from this experiment demonstrate that caloric and protein regulation mechanisms may not be controlling the intake of obese and lean rats as precisely as once believed.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalPhysiology and Behavior
Issue number1
StatePublished - 1984


  • Caloric regulation
  • Diet selection
  • Dilution
  • Motivation

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience


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