Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS

M. Kassim Javaid, Daniel Prieto-Alhambra, Li Yung Lui, Peggy Cawthon, Nigel K. Arden, Thomas Lang, Nancy E Lane, Eric Orwoll, Elizabeth Barrett-Conner, Michael C. Nevitt, Cyrus Cooper, Steven R. Cummings

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The mechanism whereby poor intrauterine growth increases risk of adult hip fracture is unclear. We report the association between birth weight and proximal femoral geometry and density in community-dwelling elderly men. We used self-reported birth weight, measured adult height and weight and proximal femoral quantitative computed tomography (QCT) measurements of femoral neck axis length, cross-sectional area, and volumetric BMD (vBMD) among the participants in the Osteoporotic Fractures in Men (MrOS), a cohort study of community-dwelling US men aged 65 and older. We compared men with birth weight <7 pounds (lower birth weight [LBW]; n=501) and ≥9 pounds (higher birth weight [HBW]; n=262) with those weighing 7-8.9 pounds (medium birth weight [MBW], referent group; n=1068) using linear regression adjusting for current age, height, and BMI. The mean age of the 1831 men who had both birth weight and QCT measurements was 73 years (SD 5.9). Compared with the referent MBW, HBW men had concordantly longer femoral neck (+0.16 SD; p=.028) and cross-sectional area (+0.24 SD, p=.001). LBW men had a smaller cross-sectional (-0.26 SD, p<.001) but longer femoral neck for their height (+0.11 SD, p=.05). Neither cortical nor trabecular vBMD at the femoral neck was associated with birth weight. These findings support the hypothesis that the skeletal envelope, but not density, is set, in part, at birth. Further research exploring the association between early developmental factors and lifetime fracture risk is needed and may inform primary preventative strategies for fracture prevention.

Original languageEnglish (US)
Pages (from-to)1802-1807
Number of pages6
JournalJournal of Bone and Mineral Research
Volume26
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • birth weight
  • CT
  • femoral geometry
  • growth
  • programming

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS'. Together they form a unique fingerprint.

  • Cite this

    Javaid, M. K., Prieto-Alhambra, D., Lui, L. Y., Cawthon, P., Arden, N. K., Lang, T., Lane, N. E., Orwoll, E., Barrett-Conner, E., Nevitt, M. C., Cooper, C., & Cummings, S. R. (2011). Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS. Journal of Bone and Mineral Research, 26(8), 1802-1807. https://doi.org/10.1002/jbmr.411