Self-organization and the self-assembling process in Tissue engineering

Kyriacos A. Athanasiou, Rajalakshmanan Eswaramoorthy, Pasha Hadidi, Jerry C. Hu

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

In recent years, the tissue engineering paradigm has shifted to include a new and growing subfield of scaffoldless techniques that generate self-organizing and self-assembling tissues. This review aims to cogently describe this relatively new research area, with special focus on applications toward clinical use and research models. Particular emphasis is placed on providing clear definitions of self-organization and the self-assembling process, as delineated from other scaffoldless techniques in tissue engineering and regenerative medicine. Significantly, during formation, self-organizing and self-assembling tissues display biological processes similar to those that occur in vivo. These processes help lead to the recapitulation of native tissue morphological structure and organization. Notably, functional properties of these engineered tissues, some of which are already in clinical trials, also approach native tissue values. This review endeavors to provide a cohesive summary of work in this field and to highlight the potential of self-organization and the self-assembling process for providing cogent solutions to currently intractable problems in tissue engineering.

Original languageEnglish (US)
Pages (from-to)115-136
Number of pages22
JournalAnnual Review of Biomedical Engineering
Volume15
DOIs
StatePublished - Jul 2013

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Tissue Engineering
Tissue engineering
Tissue
Biological Phenomena
Regenerative Medicine
Research
Clinical Trials

Keywords

  • clinical translation
  • regenerative medicine
  • scaffoldless
  • self-assembling process
  • self-organization
  • tissue engineering

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Self-organization and the self-assembling process in Tissue engineering. / Athanasiou, Kyriacos A.; Eswaramoorthy, Rajalakshmanan; Hadidi, Pasha; Hu, Jerry C.

In: Annual Review of Biomedical Engineering, Vol. 15, 07.2013, p. 115-136.

Research output: Contribution to journalArticle

Athanasiou, Kyriacos A. ; Eswaramoorthy, Rajalakshmanan ; Hadidi, Pasha ; Hu, Jerry C. / Self-organization and the self-assembling process in Tissue engineering. In: Annual Review of Biomedical Engineering. 2013 ; Vol. 15. pp. 115-136.
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