Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics

Peter P. Egeghy, Leena Nylander-French, Kristin K. Gwin, Irva Hertz-Picciotto, Stephen M. Rappaport

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Automobile mechanics are exposed to benzene through their contact with gasoline vapor and engine exhaust. This study investigated the benzene uptake associated with these exposures. We first evaluated the reliability of self-collected breath samples among a subset of subjects and found good agreement between these samples and those collected under expert supervision (intraclass correlation coefficient 0.79, n = 69). We then used self-monitoring together with a longitudinal sampling design (with up to three measurements per worker) to measure benzene in air and benzene in end-exhaled breath among 81 workers from 12 automobile repair garages in North Carolina. A statistically significant difference (P < 0.0001, Mann-Whitney rank sum test) was observed between non-smokers and smokers for post-exposure benzene concentration in breath (median values of 18.9 and 39.1 μg/m3, respectively). Comparing pre- and postexposure breath concentrations within these two groups, the difference was significant among non-smokers (P < 0.0001) but not significant among smokers (P > 0.05). Mixed effects regression analysis using backwards elimination yielded five significant predictors of benzene concentration in breath, namely benzene exposure (P < 0.0001), pre-exposure benzene concentration in breath (P = 0.021), smoking status (P < 0.0001), fuel system work (P = 0.0043) and carburetor cleaner use (P < 0.0001). The between-person variance component comprised only 28% of the total variance in benzene levels in breath, indicating that differences among individuals related to physiological and metabolic characteristics had little influence on benzene uptake among these workers.

Original languageEnglish (US)
Pages (from-to)489-500
Number of pages12
JournalAnnals of Occupational Hygiene
Volume46
Issue number5
DOIs
StatePublished - Jul 2002
Externally publishedYes

Fingerprint

Automobiles
Benzene
Mechanics
Vehicle Emissions
Gasoline
Individuality
Smoking
Air
Regression Analysis

Keywords

  • Automobile mechanics
  • Benzene
  • Biological monitoring
  • Breath analysis
  • Exhaled air
  • Gasoline
  • Mixed models
  • Self-monitoring

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health Professions(all)

Cite this

Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics. / Egeghy, Peter P.; Nylander-French, Leena; Gwin, Kristin K.; Hertz-Picciotto, Irva; Rappaport, Stephen M.

In: Annals of Occupational Hygiene, Vol. 46, No. 5, 07.2002, p. 489-500.

Research output: Contribution to journalArticle

Egeghy, Peter P. ; Nylander-French, Leena ; Gwin, Kristin K. ; Hertz-Picciotto, Irva ; Rappaport, Stephen M. / Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics. In: Annals of Occupational Hygiene. 2002 ; Vol. 46, No. 5. pp. 489-500.
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