Abstract
Molecular-level control over surface chemistry and topology is critical for the design of biologically active synthetic surfaces. Such surfaces must present active biological ligands in defined conformations, orientations, concentrations, and spatial distributions so as to foster biospecific interactions and inhibit nonspecific ones. Self-assembled monolayers (SAMs)-spontaneously organized monomolecular assemblies at solid surfaces-provide an elegant and versatile means to endow synthetic surfaces with such exquisite level of control at the molecular level. This chapter reviews the essential physical-chemical foundation for the preparation, structure, and formation mechanisms of SAMs; presents their amenability for spatial control using tools of micro-and nanopatterning; and highlights their enabling capacity for a broad range of biomolecular functionalization.
| Original language | English (US) |
|---|---|
| Title of host publication | Handbook of Biofunctional Surfaces |
| Publisher | Pan Stanford Publishing Pte. Ltd. |
| Pages | 1-29 |
| Number of pages | 29 |
| ISBN (Print) | 9789814316637 |
| DOIs | |
| State | Published - Apr 30 2013 |
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ASJC Scopus subject areas
- Medicine(all)
- Materials Science(all)
Cite this
Self-assembled monolayers : A versatile tool for biofunctionalization of surfaces. / Parikh, Atul N.; Allara, David L.
Handbook of Biofunctional Surfaces. Pan Stanford Publishing Pte. Ltd., 2013. p. 1-29.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Self-assembled monolayers
T2 - A versatile tool for biofunctionalization of surfaces
AU - Parikh, Atul N.
AU - Allara, David L.
PY - 2013/4/30
Y1 - 2013/4/30
N2 - Molecular-level control over surface chemistry and topology is critical for the design of biologically active synthetic surfaces. Such surfaces must present active biological ligands in defined conformations, orientations, concentrations, and spatial distributions so as to foster biospecific interactions and inhibit nonspecific ones. Self-assembled monolayers (SAMs)-spontaneously organized monomolecular assemblies at solid surfaces-provide an elegant and versatile means to endow synthetic surfaces with such exquisite level of control at the molecular level. This chapter reviews the essential physical-chemical foundation for the preparation, structure, and formation mechanisms of SAMs; presents their amenability for spatial control using tools of micro-and nanopatterning; and highlights their enabling capacity for a broad range of biomolecular functionalization.
AB - Molecular-level control over surface chemistry and topology is critical for the design of biologically active synthetic surfaces. Such surfaces must present active biological ligands in defined conformations, orientations, concentrations, and spatial distributions so as to foster biospecific interactions and inhibit nonspecific ones. Self-assembled monolayers (SAMs)-spontaneously organized monomolecular assemblies at solid surfaces-provide an elegant and versatile means to endow synthetic surfaces with such exquisite level of control at the molecular level. This chapter reviews the essential physical-chemical foundation for the preparation, structure, and formation mechanisms of SAMs; presents their amenability for spatial control using tools of micro-and nanopatterning; and highlights their enabling capacity for a broad range of biomolecular functionalization.
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UR - http://www.scopus.com/inward/citedby.url?scp=84881799498&partnerID=8YFLogxK
U2 - 10.4032/9789814364188
DO - 10.4032/9789814364188
M3 - Chapter
SN - 9789814316637
SP - 1
EP - 29
BT - Handbook of Biofunctional Surfaces
PB - Pan Stanford Publishing Pte. Ltd.
ER -