Selective uptake of hematoporphyrin derivative into human cerebral glioma

J. S. Hill, A. H. Kaye, W. H. Sawyer, G. Morstyn, P. D. Megison, S. S. Stylli, S. K. Powers, James E Boggan

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

The uptake of hematoporphyrin derivative (HpD) into human cerebral glioma was measured using a porphyrin extraction technique. Patients with cerebral glioma were injected with HpD at a dose of 5 mg/kg body weight 24 hours before surgery and photoradiation therapy (PRT). Biopsies of tumor, and where possible, adjacent brain and normal brain were taken for analysis of HpD uptake. HpD was selectively localized into all grades of glioma, and there was a direct correlation between the grade of glioma and HpD level in the tumor. The levels were highest in glioblastoma multiforme (mean uptake of 5.9 μg of HpD/g of tumor wet weight) and lower in the intermediate-grade anaplastic astrocytoma (mean uptake of 2.4 μg/g of tumor) and the low-grade astrocytoma (1.6 μg/g of tumor). Uptake into normal brain tissue taken from HpD-sensitized patients was 0.2 μg/g. HpD was also localized into the 'brain adjacent to tumor' region. The selective uptake into the low-grade glioma suggests that PRT may be of use as an adjuvant therapy in these tumors and the detection of HpD in this region indicates that PRT may control the spread of tumor infiltrating into the adjacent normal brain.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalNeurosurgery
Volume26
Issue number2
StatePublished - 1990
Externally publishedYes

Keywords

  • brain tumor
  • fluorescence spectroscopy
  • glioma
  • hematoporphyrin derivative
  • photoradiation therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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