Selective pulmonary vasodilators

Maurice Beghetti, Robin H Steinhorn

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nitric oxide (NO) is synthesized by the enzyme nitric oxide synthase (NOS) as a product of the conversion of l-arginine to l-citrulline. Three NOS isoforms are expressed in the lung, which are characterized by the regulation of their activities and by specific sites and developmental patterns of expression (Shaul 2002). Endothelial NOS (NOS3) is expressed in vascular endothelial cells and is the predominant source of NO production in the pulmonary circulation. Neuronal NOS (NOS1) and inducible NOS (NOS2) are boThexpressed in the airway epithelium and at low levels in the vascular smooth muscle. Furthermore, the expression of NOS2 can be induced in a variety of pulmonary cell types by exposure to endotoxin or inflammatory cytokines.

Original languageEnglish (US)
Title of host publicationPediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice
PublisherSpringer Berlin Heidelberg
Pages809-836
Number of pages28
ISBN (Print)9783642012198, 9783642012181
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)

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    Beghetti, M., & Steinhorn, R. H. (2015). Selective pulmonary vasodilators. In Pediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice (pp. 809-836). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-01219-8_29