Nitric oxide (NO) is synthesized by the enzyme nitric oxide synthase (NOS) as a product of the conversion of l-arginine to l-citrulline. Three NOS isoforms are expressed in the lung, which are characterized by the regulation of their activities and by specific sites and developmental patterns of expression (Shaul 2002). Endothelial NOS (NOS3) is expressed in vascular endothelial cells and is the predominant source of NO production in the pulmonary circulation. Neuronal NOS (NOS1) and inducible NOS (NOS2) are boThexpressed in the airway epithelium and at low levels in the vascular smooth muscle. Furthermore, the expression of NOS2 can be induced in a variety of pulmonary cell types by exposure to endotoxin or inflammatory cytokines.
|Original language||English (US)|
|Title of host publication||Pediatric and Neonatal Mechanical Ventilation: From Basics to Clinical Practice|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||28|
|ISBN (Print)||9783642012198, 9783642012181|
|State||Published - Jan 1 2015|
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