Selective photocleavage of DNA and RNA by anthraquinone derivatives: Targeting the single-strand region of hairpin structures

Maria Fernandez-Saiz, Paul Henderson, W. David Wilson, Gary B. Schuster

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A tetracationic anthraquinone derivative (27AQS2) binds to hairpin DNA and RNA. Ultraviolet irradiation of the bound quinone causes cleavage in the loop region of both oligonucleotides and at guanines in the stem region of the DNA hairpin. The absence of observable strand cleavage at guanines in the RNA hairpin suggests that either aniline treatment does not cause cleavage at damaged guanines in RNA or that radical cation migration does not occur readily in RNA duplexes. The ability to target the single-stranded regions of DNA and RNA structures is an important property of this photonuclease.

Original languageEnglish (US)
Pages (from-to)847-852
Number of pages6
JournalPhotochemistry and Photobiology
Volume70
Issue number6
StatePublished - Dec 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

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