Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells

Asish C. Misra, Tae Hong Park, Randy P. Carney, Giulia Rusciano, Francesco Stellacci, Joerg Lahann

Research output: Contribution to journalArticle

Abstract

Particles that preferentially partition to a specific cellular subunit, such as the nucleus, mitochondria, or the cytoskeleton, are of relevance to a number of applications, including drug delivery, genetic manipulation, or self-assembly. Here, hierarchical assemblies of fully synthetic particles that selectively localize to the plasma membrane of mammalian cells are presented. A multimodal approach is used to create assemblies of polymer-based carrier particles with amphiphilic gold nanoparticles immobilized on one hemisphere. These assemblies persist in the plasma membrane of cells for several days and undergo rearrangements and clustering, typically considered to be hallmarks of membrane-bound receptors.

Original languageEnglish (US)
Article number1800408
JournalSmall Methods
Volume3
Issue number5
DOIs
StatePublished - May 1 2019
Externally publishedYes

Keywords

  • nanoparticles
  • plasma membranes
  • subcellular targeting

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Selective Localization of Hierarchically Assembled Particles to Plasma Membranes of Living Cells'. Together they form a unique fingerprint.

  • Cite this