Selective imaging of adherent targeted ultrasound contrast agents

S. Zhao, D. E. Kruse, K. W. Ferrara, P. A. Dayton

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles from tissue and from freely circulating microbubbles, each of which would otherwise obscure signal from molecularly targeted adherent agents. The methods are based on a harmonic signal model of the returned echoes over a train of pulses. The first method utilizes an 'image-push-image' pulse sequence where adhesion of contrast agents is rapidly promoted by acoustic radiation force and the presence of adherent agents is detected by the signal change due to targeted microbubble adhesion. The second method rejects tissue echoes using a spectral high-pass filter. Free agent signal is suppressed by a pulse-to-pulse low-pass filter in both methods. An overlay of the adherent and/or flowing contrast agents on B-mode images can be readily created for anatomical reference. Contrast-to-tissue ratios from adherent microbubbles exceeding 30 dB and 20 dB were achieved for the two methods proposed, respectively. The performance of these algorithms is compared, emphasizing the significance and potential applications in ultrasonic molecular imaging.

Original languageEnglish (US)
Article number002
Pages (from-to)2055-2072
Number of pages18
JournalPhysics in Medicine and Biology
Volume52
Issue number8
DOIs
StatePublished - Apr 21 2007

Fingerprint

Contrast Media
Microbubbles
Ultrasonics
Imaging techniques
Ultrasonic imaging
Molecular imaging
Molecular Imaging
Tissue
pulses
Ultrasonography
echoes
adhesion
Adhesion
ultrasonics
high pass filters
High pass filters
low pass filters
Endothelial cells
Low pass filters
sound waves

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Zhao, S., Kruse, D. E., Ferrara, K. W., & Dayton, P. A. (2007). Selective imaging of adherent targeted ultrasound contrast agents. Physics in Medicine and Biology, 52(8), 2055-2072. [002]. https://doi.org/10.1088/0031-9155/52/8/002

Selective imaging of adherent targeted ultrasound contrast agents. / Zhao, S.; Kruse, D. E.; Ferrara, K. W.; Dayton, P. A.

In: Physics in Medicine and Biology, Vol. 52, No. 8, 002, 21.04.2007, p. 2055-2072.

Research output: Contribution to journalArticle

Zhao, S, Kruse, DE, Ferrara, KW & Dayton, PA 2007, 'Selective imaging of adherent targeted ultrasound contrast agents', Physics in Medicine and Biology, vol. 52, no. 8, 002, pp. 2055-2072. https://doi.org/10.1088/0031-9155/52/8/002
Zhao, S. ; Kruse, D. E. ; Ferrara, K. W. ; Dayton, P. A. / Selective imaging of adherent targeted ultrasound contrast agents. In: Physics in Medicine and Biology. 2007 ; Vol. 52, No. 8. pp. 2055-2072.
@article{74911d1a12a54c1c917d7a7814fd639f,
title = "Selective imaging of adherent targeted ultrasound contrast agents",
abstract = "The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles from tissue and from freely circulating microbubbles, each of which would otherwise obscure signal from molecularly targeted adherent agents. The methods are based on a harmonic signal model of the returned echoes over a train of pulses. The first method utilizes an 'image-push-image' pulse sequence where adhesion of contrast agents is rapidly promoted by acoustic radiation force and the presence of adherent agents is detected by the signal change due to targeted microbubble adhesion. The second method rejects tissue echoes using a spectral high-pass filter. Free agent signal is suppressed by a pulse-to-pulse low-pass filter in both methods. An overlay of the adherent and/or flowing contrast agents on B-mode images can be readily created for anatomical reference. Contrast-to-tissue ratios from adherent microbubbles exceeding 30 dB and 20 dB were achieved for the two methods proposed, respectively. The performance of these algorithms is compared, emphasizing the significance and potential applications in ultrasonic molecular imaging.",
author = "S. Zhao and Kruse, {D. E.} and Ferrara, {K. W.} and Dayton, {P. A.}",
year = "2007",
month = "4",
day = "21",
doi = "10.1088/0031-9155/52/8/002",
language = "English (US)",
volume = "52",
pages = "2055--2072",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "8",

}

TY - JOUR

T1 - Selective imaging of adherent targeted ultrasound contrast agents

AU - Zhao, S.

AU - Kruse, D. E.

AU - Ferrara, K. W.

AU - Dayton, P. A.

PY - 2007/4/21

Y1 - 2007/4/21

N2 - The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles from tissue and from freely circulating microbubbles, each of which would otherwise obscure signal from molecularly targeted adherent agents. The methods are based on a harmonic signal model of the returned echoes over a train of pulses. The first method utilizes an 'image-push-image' pulse sequence where adhesion of contrast agents is rapidly promoted by acoustic radiation force and the presence of adherent agents is detected by the signal change due to targeted microbubble adhesion. The second method rejects tissue echoes using a spectral high-pass filter. Free agent signal is suppressed by a pulse-to-pulse low-pass filter in both methods. An overlay of the adherent and/or flowing contrast agents on B-mode images can be readily created for anatomical reference. Contrast-to-tissue ratios from adherent microbubbles exceeding 30 dB and 20 dB were achieved for the two methods proposed, respectively. The performance of these algorithms is compared, emphasizing the significance and potential applications in ultrasonic molecular imaging.

AB - The goal of ultrasonic molecular imaging is the detection of targeted contrast agents bound to receptors on endothelial cells. We propose imaging methods that can distinguish adherent microbubbles from tissue and from freely circulating microbubbles, each of which would otherwise obscure signal from molecularly targeted adherent agents. The methods are based on a harmonic signal model of the returned echoes over a train of pulses. The first method utilizes an 'image-push-image' pulse sequence where adhesion of contrast agents is rapidly promoted by acoustic radiation force and the presence of adherent agents is detected by the signal change due to targeted microbubble adhesion. The second method rejects tissue echoes using a spectral high-pass filter. Free agent signal is suppressed by a pulse-to-pulse low-pass filter in both methods. An overlay of the adherent and/or flowing contrast agents on B-mode images can be readily created for anatomical reference. Contrast-to-tissue ratios from adherent microbubbles exceeding 30 dB and 20 dB were achieved for the two methods proposed, respectively. The performance of these algorithms is compared, emphasizing the significance and potential applications in ultrasonic molecular imaging.

UR - http://www.scopus.com/inward/record.url?scp=34147133200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34147133200&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/52/8/002

DO - 10.1088/0031-9155/52/8/002

M3 - Article

VL - 52

SP - 2055

EP - 2072

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 8

M1 - 002

ER -