Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices

Helen E. Scharfman, Philip A Schwartzkroin

Research output: Contribution to journalArticle

54 Scopus citations


In area CA1 of hippocampus, a subpopulation of γ-aminobutyric acid (GABA)-containing interneurons that make synaptic contacts on pyramidal cells also contains the neuropeptide, somatostatin. The effects of GABA and somatostatin on hippocampal pyramidal cells have been investigated separately, but it is not known whether an interaction occurs between these co-localized substances. We demonstrate that somatostatin has a potent inhibitory effect on GABA-mediated synaptic potentials which hyperpolarize pyramidal cells. This effect may be relevant to the well-documented epileptogenicity of the hippocampus, as well as the phenomenon of long-term potentiation, which is a well-studied example of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalBrain Research
Issue number2
StatePublished - Jul 31 1989
Externally publishedYes



  • Excitatory postsynaptic potential
  • Hippocampal slice
  • Inhibitory postsynaptic potential
  • Pressure application
  • Somatostatin
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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