The synthesis of 1-(p-benzenediazonium)ethylenediaminetetraacetic acid, the coupling of this compound to proteins, and the binding of radioactive metal ions to the protein-bound chelating groups are described. This procedure provides a novel approach to the preparation of radiopharmaceuticals, permitting the separation of synthetic organic chemistry from radiochemistry. Azoproteins labeled with indium-111 are relatively stable in vivo and potentially useful for the detection and localization of tumors. Other chelating agents derived from 1-(p-aminophenyl)ethylenediaminetetraacetic acid may permit new applications of a variety of metal ions with useful physical properties to studies of biological systems.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Medicinal Chemistry|
|State||Published - 1974|
ASJC Scopus subject areas
- Organic Chemistry