Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA

Michael W. Sundberg, Claude F. Meares, David A. Goodwin, Carol I. Diamanti

Research output: Contribution to journalArticle

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Abstract

The synthesis of 1-(p-benzenediazonium)ethylenediaminetetraacetic acid, the coupling of this compound to proteins, and the binding of radioactive metal ions to the protein-bound chelating groups are described. This procedure provides a novel approach to the preparation of radiopharmaceuticals, permitting the separation of synthetic organic chemistry from radiochemistry. Azoproteins labeled with indium-111 are relatively stable in vivo and potentially useful for the detection and localization of tumors. Other chelating agents derived from 1-(p-aminophenyl)ethylenediaminetetraacetic acid may permit new applications of a variety of metal ions with useful physical properties to studies of biological systems.

Original languageEnglish (US)
Pages (from-to)1304-1307
Number of pages4
JournalJournal of Medicinal Chemistry
Volume17
Issue number12
StatePublished - 1974

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Sundberg, M. W., Meares, C. F., Goodwin, D. A., & Diamanti, C. I. (1974). Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA. Journal of Medicinal Chemistry, 17(12), 1304-1307.