Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA

Michael W. Sundberg, Claude F. Meares, David A. Goodwin, Carol I. Diamanti

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

The synthesis of 1-(p-benzenediazonium)ethylenediaminetetraacetic acid, the coupling of this compound to proteins, and the binding of radioactive metal ions to the protein-bound chelating groups are described. This procedure provides a novel approach to the preparation of radiopharmaceuticals, permitting the separation of synthetic organic chemistry from radiochemistry. Azoproteins labeled with indium-111 are relatively stable in vivo and potentially useful for the detection and localization of tumors. Other chelating agents derived from 1-(p-aminophenyl)ethylenediaminetetraacetic acid may permit new applications of a variety of metal ions with useful physical properties to studies of biological systems.

Original languageEnglish (US)
Pages (from-to)1304-1307
Number of pages4
JournalJournal of Medicinal Chemistry
Volume17
Issue number12
StatePublished - 1974

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Macromolecules
Edetic Acid
Metal ions
Radiochemistry
Metals
Organic Chemistry
Ions
Indium
Radiopharmaceuticals
Biological systems
Chelating Agents
Chelation
Protein Binding
Tumors
Proteins
Physical properties
Neoplasms
benzenediazonium

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Sundberg, M. W., Meares, C. F., Goodwin, D. A., & Diamanti, C. I. (1974). Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA. Journal of Medicinal Chemistry, 17(12), 1304-1307.

Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA. / Sundberg, Michael W.; Meares, Claude F.; Goodwin, David A.; Diamanti, Carol I.

In: Journal of Medicinal Chemistry, Vol. 17, No. 12, 1974, p. 1304-1307.

Research output: Contribution to journalArticle

Sundberg, MW, Meares, CF, Goodwin, DA & Diamanti, CI 1974, 'Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA', Journal of Medicinal Chemistry, vol. 17, no. 12, pp. 1304-1307.
Sundberg, Michael W. ; Meares, Claude F. ; Goodwin, David A. ; Diamanti, Carol I. / Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA. In: Journal of Medicinal Chemistry. 1974 ; Vol. 17, No. 12. pp. 1304-1307.
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