Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: Arthritis decreases while carditis persists

Juan Anguita, Stephen W Barthold, Swapna Samanta, John Ryan, Erol Fikrig

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.

Original languageEnglish (US)
Pages (from-to)734-737
Number of pages4
JournalJournal of Infectious Diseases
Volume179
Issue number3
DOIs
StatePublished - 1999

Fingerprint

Interleukin-11
Lyme Disease
Myocarditis
Anti-Inflammatory Agents
Borrelia burgdorferi
Blocking Antibodies
Nitric Oxide Synthase Type II
Interleukin-12
Innate Immunity
Interleukin-4
Interferons
Arthritis
Joints
Cytokines
Inflammation
Messenger RNA
Antibodies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Selective anti-inflammatory action of interleukin-11 in murine Lyme disease : Arthritis decreases while carditis persists. / Anguita, Juan; Barthold, Stephen W; Samanta, Swapna; Ryan, John; Fikrig, Erol.

In: Journal of Infectious Diseases, Vol. 179, No. 3, 1999, p. 734-737.

Research output: Contribution to journalArticle

@article{24230078edf14adcac049b6a34abd81d,
title = "Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: Arthritis decreases while carditis persists",
abstract = "The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.",
author = "Juan Anguita and Barthold, {Stephen W} and Swapna Samanta and John Ryan and Erol Fikrig",
year = "1999",
doi = "10.1086/314613",
language = "English (US)",
volume = "179",
pages = "734--737",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Selective anti-inflammatory action of interleukin-11 in murine Lyme disease

T2 - Arthritis decreases while carditis persists

AU - Anguita, Juan

AU - Barthold, Stephen W

AU - Samanta, Swapna

AU - Ryan, John

AU - Fikrig, Erol

PY - 1999

Y1 - 1999

N2 - The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.

AB - The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.

UR - http://www.scopus.com/inward/record.url?scp=0033388911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033388911&partnerID=8YFLogxK

U2 - 10.1086/314613

DO - 10.1086/314613

M3 - Article

C2 - 9952389

AN - SCOPUS:0033388911

VL - 179

SP - 734

EP - 737

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -