Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: Arthritis decreases while carditis persists

Juan Anguita, Stephen W Barthold, Swapna Samanta, John Ryan, Erol Fikrig

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Abstract

The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.

Original languageEnglish (US)
Pages (from-to)734-737
Number of pages4
JournalJournal of Infectious Diseases
Volume179
Issue number3
DOIs
StatePublished - 1999

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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