Abstract
The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 734-737 |
| Number of pages | 4 |
| Journal | Journal of Infectious Diseases |
| Volume | 179 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1999 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
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Selective anti-inflammatory action of interleukin-11 in murine Lyme disease : Arthritis decreases while carditis persists. / Anguita, Juan; Barthold, Stephen W; Samanta, Swapna; Ryan, John; Fikrig, Erol.
In: Journal of Infectious Diseases, Vol. 179, No. 3, 1999, p. 734-737.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective anti-inflammatory action of interleukin-11 in murine Lyme disease
T2 - Arthritis decreases while carditis persists
AU - Anguita, Juan
AU - Barthold, Stephen W
AU - Samanta, Swapna
AU - Ryan, John
AU - Fikrig, Erol
PY - 1999
Y1 - 1999
N2 - The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.
AB - The role of interleukin (IL)-11, a cytokine with potent anti- inflammatory properties, in murine Lyme disease was investigated. Borrelia burgdorferi-infected mice treated with IL-11 developed less arthritis than did control animals. In contrast, IL-11 blocking antibodies increased Lyme arthritis. Murine Lyme cardiris was not affected by either IL-11 or IL-11 antibodies. Administration of IL-11 was associated with increased production of mRNA for IL-12 and inducible nitric oxide synthase but not interferon-γ or IL-4 in B. burgdorferi-infected mice, suggesting a predominant effect of IL-11 on the innate immune response. These data show that IL-11 selectively reduced joint but not cardiac inflammation caused by B. burgdorferi in mice.
UR - http://www.scopus.com/inward/record.url?scp=0033388911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033388911&partnerID=8YFLogxK
U2 - 10.1086/314613
DO - 10.1086/314613
M3 - Article
C2 - 9952389
AN - SCOPUS:0033388911
VL - 179
SP - 734
EP - 737
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 3
ER -