Selection of silk-binding peptides by phage display

Yoko Nomura, Vandana Sharma, Asami Yamamura, Yohei Yokobayashi

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Peptides that bind to silkworm-derived silk fibroin fiber were selected from a phage-displayed random peptide library. The selected silk-binding peptides contained a consensus sequence QSWS which is important for silk-binding as confirmed by binding assays using phage and synthetic peptides. With further optimization, we anticipate that the silk-binding peptides will be useful for functionalization of silk for biomaterial applications.

Original languageEnglish (US)
Pages (from-to)1069-1073
Number of pages5
JournalBiotechnology Letters
Volume33
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • Fibroin fiber
  • Peptide
  • Phage display
  • Silk

ASJC Scopus subject areas

  • Biotechnology

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    Nomura, Y., Sharma, V., Yamamura, A., & Yokobayashi, Y. (2011). Selection of silk-binding peptides by phage display. Biotechnology Letters, 33(5), 1069-1073. https://doi.org/10.1007/s10529-011-0519-6