Abstract
Helicobacter pylori strain J166 recovered from experimentally inoculated rhesus monkeys had up to a 250-fold-increased urease activity over that before inoculation. This was found to result from the selection of urease positive J166 clones from a heterogenous inoculum, which was predominantly urease negative due to a 1-bp insertion in the urea gene. These results confirm the importance of urease for H. pylori colonization. Strain J166 is particularly well adapted to the rhesus monkey, since it colonized preferentially despite the fact that less than 0.1% of the inoculum was urease positive.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3519-3522 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 69 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2001 |
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ASJC Scopus subject areas
- Immunology
Cite this
Selection for urease activity during Helicobacter pylori infection of rhesus macaques (Macaca mulatta). / Hansen, L. M.; Solnick, Jay V.
In: Infection and Immunity, Vol. 69, No. 5, 2001, p. 3519-3522.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selection for urease activity during Helicobacter pylori infection of rhesus macaques (Macaca mulatta)
AU - Hansen, L. M.
AU - Solnick, Jay V
PY - 2001
Y1 - 2001
N2 - Helicobacter pylori strain J166 recovered from experimentally inoculated rhesus monkeys had up to a 250-fold-increased urease activity over that before inoculation. This was found to result from the selection of urease positive J166 clones from a heterogenous inoculum, which was predominantly urease negative due to a 1-bp insertion in the urea gene. These results confirm the importance of urease for H. pylori colonization. Strain J166 is particularly well adapted to the rhesus monkey, since it colonized preferentially despite the fact that less than 0.1% of the inoculum was urease positive.
AB - Helicobacter pylori strain J166 recovered from experimentally inoculated rhesus monkeys had up to a 250-fold-increased urease activity over that before inoculation. This was found to result from the selection of urease positive J166 clones from a heterogenous inoculum, which was predominantly urease negative due to a 1-bp insertion in the urea gene. These results confirm the importance of urease for H. pylori colonization. Strain J166 is particularly well adapted to the rhesus monkey, since it colonized preferentially despite the fact that less than 0.1% of the inoculum was urease positive.
UR - http://www.scopus.com/inward/record.url?scp=0035058621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035058621&partnerID=8YFLogxK
U2 - 10.1128/IAI.69.5.3519-3522.2001
DO - 10.1128/IAI.69.5.3519-3522.2001
M3 - Article
C2 - 11292788
AN - SCOPUS:0035058621
VL - 69
SP - 3519
EP - 3522
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 5
ER -