Selectide Technology: Substrate Motif Identification for Post-translational Modifications

Kit Lam, Jinzi Wu

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The random synthetic peptide library screening method based on the "one-bead one-peptide concept" (Selectide Process) can be used as a general method for the identification of peptide substrate motif for post-translational modifications. We applied this method to the cAMP-dependent protein kinase system and were able to rapidly identify a peptide motif (RRXS) that exactly matched that described for its natural substrates.

Original languageEnglish (US)
Pages (from-to)401-403
Number of pages3
JournalMethods
Volume6
Issue number4
DOIs
StatePublished - Dec 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology

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