Seizures: Seizure Termination and the Postseizure Refractory Period

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Why seizures stop is an important but largely unanswered question in epilepsy research. The fact that most seizures are self-limiting suggests the operation of some cellular mechanism or mechanisms to terminate ictal activity. The purpose of this review is to summarize some of what is known about why seizures, once started, stop. The roles of potassium homeostasis, GABA, adenosine, neuropeptide Y, somatostatin, and endocannabinoids in this process are considered. Understanding the cellular mechanisms that contribute to the termination of the ongoing seizure activity is important, because such information could not only provide new insights into the mechanisms of seizures (and the patterning of seizures over time), but also identify new therapeutic targets for seizure control.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Basic Epilepsy Research
PublisherElsevier Inc.
Number of pages8
ISBN (Print)9780123739612
StatePublished - Jan 1 2009


  • Adenosine
  • Afterdischarge
  • Anticonvulsant
  • Cerebral metabolism
  • Endocannabinoids
  • GABA
  • Hippocampus
  • Neuropeptide Y
  • Paroxymal depolarizing shift (PDS)
  • Postictal EEG depression
  • Refractory period
  • Somatostatin

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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