The nitrogen mustard derivative, chlorambucil, has been used with minimal side effects in children for the treatment of nephrotic syndrome. Although bone marrow suppression with leukopenia, increased susceptibility to overwhelming infection, and a variety of mild gastrointestinal symptoms have been reported, seizures have not been previously described. We report here seven of 91 children (3 boys, 4 girls) treated with 99 courses of chlorambucil, given orally, who had seizures during or immediately following therapy.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Pediatrics|
|State||Published - 1978|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health