Secretion of lysosomal enzymes by human placental villi in vitro

Gordon C Douglas, Alan Mackenzie

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Chorionic villi from first trimester and term human placentas have been incubated in vitro and shown to release the lysosomal enzymes, β-hexosaminidase, α-glucosidase and β-gluctlronidase. There was negligible release of the cytoplasmic enzyme, lactate dehydrogenase, under the same conditions. The first trimester villi released proportionally more of their lysosomal enzyme content than did the term villi. Extracellular levels of β-hexosaminidase were raised and those of α-glucosidase and, β-glucuronidase were lowered when tissue was incubated with 1 μM colchicine, suggesting that microtubules are involved in the control of lysosomal enzyme release from placental villi.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalMolecular and Cellular Biochemistry
Volume33
Issue number1-2
DOIs
StatePublished - Dec 1980
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Cell Biology

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