Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway

Helen E Raybould; Helge Holzer

doi:10.1016/0014-2999(93)90636-V

Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway

Helen E Raybould, Helge Holzer

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

Original language	English (US)
Pages (from-to)	165-167
Number of pages	3
Journal	European Journal of Pharmacology
Volume	250
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(93)90636-V
State	Published - Nov 30 1993

Keywords

Capsaicin
CCK (cholecystokinin)
Gastric emptying
Secretin
Spinal afferent
Vagal afferent

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/0014-2999(93)90636-V

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title = "Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway",

abstract = "In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.",

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AU - Raybould, Helen E

AU - Holzer, Helge

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N2 - In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

AB - In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

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KW - Secretin

KW - Spinal afferent

KW - Vagal afferent

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Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway

Abstract

Keywords

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