Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway

Helen E Raybould, Helge Holzer

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

Original languageEnglish (US)
Pages (from-to)165-167
Number of pages3
JournalEuropean Journal of Pharmacology
Volume250
Issue number1
DOIs
StatePublished - Nov 30 1993

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Keywords

  • Capsaicin
  • CCK (cholecystokinin)
  • Gastric emptying
  • Secretin
  • Spinal afferent
  • Vagal afferent

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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