Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway

Helen E Raybould, Helge Holzer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

Original languageEnglish (US)
Pages (from-to)165-167
Number of pages3
JournalEuropean Journal of Pharmacology
Volume250
Issue number1
DOIs
StatePublished - Nov 30 1993

Fingerprint

Afferent Pathways
Secretin
Gastric Emptying
Capsaicin
Visceral Afferents
Gastric Fistula
Cholecystokinin
Meals
Hormones

Keywords

  • Capsaicin
  • CCK (cholecystokinin)
  • Gastric emptying
  • Secretin
  • Spinal afferent
  • Vagal afferent

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway. / Raybould, Helen E; Holzer, Helge.

In: European Journal of Pharmacology, Vol. 250, No. 1, 30.11.1993, p. 165-167.

Research output: Contribution to journalArticle

@article{e756a9c277b64317bc8cb732bc645239,
title = "Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway",
abstract = "In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16{\%} (NS) and 38{\%} (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61{\%}. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50{\%} by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.",
keywords = "Capsaicin, CCK (cholecystokinin), Gastric emptying, Secretin, Spinal afferent, Vagal afferent",
author = "Raybould, {Helen E} and Helge Holzer",
year = "1993",
month = "11",
day = "30",
doi = "10.1016/0014-2999(93)90636-V",
language = "English (US)",
volume = "250",
pages = "165--167",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway

AU - Raybould, Helen E

AU - Holzer, Helge

PY - 1993/11/30

Y1 - 1993/11/30

N2 - In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

AB - In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.

KW - Capsaicin

KW - CCK (cholecystokinin)

KW - Gastric emptying

KW - Secretin

KW - Spinal afferent

KW - Vagal afferent

UR - http://www.scopus.com/inward/record.url?scp=0027434213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027434213&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(93)90636-V

DO - 10.1016/0014-2999(93)90636-V

M3 - Article

C2 - 8119315

AN - SCOPUS:0027434213

VL - 250

SP - 165

EP - 167

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -