Abstract
In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.
Original language | English (US) |
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Pages (from-to) | 165-167 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 250 |
Issue number | 1 |
DOIs | |
State | Published - Nov 30 1993 |
Keywords
- Capsaicin
- CCK (cholecystokinin)
- Gastric emptying
- Secretin
- Spinal afferent
- Vagal afferent
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology