Abstract
In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-167 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 250 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 30 1993 |
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Keywords
- Capsaicin
- CCK (cholecystokinin)
- Gastric emptying
- Secretin
- Spinal afferent
- Vagal afferent
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway. / Raybould, Helen E; Holzer, Helge.
In: European Journal of Pharmacology, Vol. 250, No. 1, 30.11.1993, p. 165-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway
AU - Raybould, Helen E
AU - Holzer, Helge
PY - 1993/11/30
Y1 - 1993/11/30
N2 - In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.
AB - In awake rats, fitted with chronic gastric fistulas, secretin (30 and 300 pmol intraperitoneal, i.p.) inhibited gastric emptying of a non-nutrient liquid by 16% (NS) and 38% (P < 0.01) respectively. Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%. Inhibition of gastric emptying induced by cholecystokinin (CCK) (30 pmol i.p.) was reversed by around 50% by ablation of either the vagal or spinal capsaicin-sensitive afferent pathway. These results suggest that hormones released after a meal can inhibit gastric emptying via activation of visceral afferent pathways.
KW - Capsaicin
KW - CCK (cholecystokinin)
KW - Gastric emptying
KW - Secretin
KW - Spinal afferent
KW - Vagal afferent
UR - http://www.scopus.com/inward/record.url?scp=0027434213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027434213&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(93)90636-V
DO - 10.1016/0014-2999(93)90636-V
M3 - Article
C2 - 8119315
AN - SCOPUS:0027434213
VL - 250
SP - 165
EP - 167
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -