Abstract
The objectives of this pilot study were 1) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism, and 2) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism. Participants were a subset of subjects from two double blind, placebo-control, multi-center clinical trials. One trial, the UC Irvine study, assessed the effects of porcine secretin vs. saline infusions on children's behavior, language and IQ. The UC Davis trial assessed the effects of synthetic human secretin vs. saline infusions on behavior, language and gastrointestinal function. The sleep study enrolled some of the children from each of the two trials to observe possible secretin effects on sleep. To examine sleep, the UC Irvine trial used the Children's Sleep Habits Questionnaire and daily sleep diaries, whereas the UC Davis study used home-recorded time-lapse video-somnography. Because of the small sample size, the results from both trials are preliminary. They suggest that secretin, porcine or synthetic, does not improve sleep-wake state organization dramatically.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-123 |
| Number of pages | 17 |
| Journal | Child Psychiatry and Human Development |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| State | Published - Dec 2002 |
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Keywords
- Autism
- Secretin
- Sleep
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Psychiatry and Mental health
- Developmental and Educational Psychology
Cite this
Secretin and sleep in children with autism. / Honomichl, Ryan D.; Goodlin-Jones, Beth L.; Burnham, Melissa M.; Hansen, Robin L; Anders, Thomas F.
In: Child Psychiatry and Human Development, Vol. 33, No. 2, 12.2002, p. 107-123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Secretin and sleep in children with autism
AU - Honomichl, Ryan D.
AU - Goodlin-Jones, Beth L.
AU - Burnham, Melissa M.
AU - Hansen, Robin L
AU - Anders, Thomas F.
PY - 2002/12
Y1 - 2002/12
N2 - The objectives of this pilot study were 1) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism, and 2) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism. Participants were a subset of subjects from two double blind, placebo-control, multi-center clinical trials. One trial, the UC Irvine study, assessed the effects of porcine secretin vs. saline infusions on children's behavior, language and IQ. The UC Davis trial assessed the effects of synthetic human secretin vs. saline infusions on behavior, language and gastrointestinal function. The sleep study enrolled some of the children from each of the two trials to observe possible secretin effects on sleep. To examine sleep, the UC Irvine trial used the Children's Sleep Habits Questionnaire and daily sleep diaries, whereas the UC Davis study used home-recorded time-lapse video-somnography. Because of the small sample size, the results from both trials are preliminary. They suggest that secretin, porcine or synthetic, does not improve sleep-wake state organization dramatically.
AB - The objectives of this pilot study were 1) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism, and 2) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism. Participants were a subset of subjects from two double blind, placebo-control, multi-center clinical trials. One trial, the UC Irvine study, assessed the effects of porcine secretin vs. saline infusions on children's behavior, language and IQ. The UC Davis trial assessed the effects of synthetic human secretin vs. saline infusions on behavior, language and gastrointestinal function. The sleep study enrolled some of the children from each of the two trials to observe possible secretin effects on sleep. To examine sleep, the UC Irvine trial used the Children's Sleep Habits Questionnaire and daily sleep diaries, whereas the UC Davis study used home-recorded time-lapse video-somnography. Because of the small sample size, the results from both trials are preliminary. They suggest that secretin, porcine or synthetic, does not improve sleep-wake state organization dramatically.
KW - Autism
KW - Secretin
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=0036889252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036889252&partnerID=8YFLogxK
U2 - 10.1023/A:1020778108068
DO - 10.1023/A:1020778108068
M3 - Article
VL - 33
SP - 107
EP - 123
JO - Child Psychiatry and Human Development
JF - Child Psychiatry and Human Development
SN - 0009-398X
IS - 2
ER -