Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis

Shuping Zhang, L. Garry Adams, Jairo Nunes, Sangeeta Khare, Renee M Tsolis, Andreas J Baumler

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Infection of bovine ligated loops with the Salmonella enterica serotype Typhimurium wild type but not a sipA sopABDE2 mutant resulted in fluid accumulation, polymorphonuclear cell infiltration, and expression of CXC chemokines, particularly GROα. None of these sipA sopABDE2-dependent responses was observed in murine ligated loops. The majority of GROα transcripts localized to bovine intestinal epithelium. Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells.

Original languageEnglish (US)
Pages (from-to)4795-4803
Number of pages9
JournalInfection and Immunity
Volume71
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

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Enterocolitis
CXC Chemokines
Salmonella enterica
Typhoid Fever
Chemokines
Animal Models
Intestinal Mucosa
Diarrhea
Proteins
Epithelial Cells
Gene Expression
Infection
Serogroup

ASJC Scopus subject areas

  • Immunology

Cite this

Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis. / Zhang, Shuping; Adams, L. Garry; Nunes, Jairo; Khare, Sangeeta; Tsolis, Renee M; Baumler, Andreas J.

In: Infection and Immunity, Vol. 71, No. 8, 01.08.2003, p. 4795-4803.

Research output: Contribution to journalArticle

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