Second-Hand Smoke is an Adjuvant for T Helper-2 Responses in a Murine Model of Allergy

Brian W P Seymour, Kent E Pinkerton, Kathleen E. Friebertshauser, Robert L. Coffman, Laurel J Gershwin

Research output: Contribution to journalArticle

109 Scopus citations

Abstract

Epidemiologic studies have suggested that "second-hand smoke" increases the incidence and severity of allergies and asthma. To address this, we developed a murine model that included generation of and exposure to environmental tobacco smoke (ETS) followed by aerosolized Ag challenge. We report herein that exposure of OVA-sensitized BALB/c mice to ETS elicits a rapid and prolonged exaggerated response with respect to IgE, IgG1, eosinophils, and Th2 cytokines (particularly IL-4 and IL-10). There was a significant increase (p = 0.0159) in the total cells of the bronchoalveolar lavage in OVA-sensitized mice exposed to ETS when compared with those in ambient air. This is the first experimental data to demonstrate that "second-hand smoke" up-regulates the allergic response to inhaled Ag. The results have important health implications for children and allergic individuals residing in households with smokers.

Original languageEnglish (US)
Pages (from-to)6169-6175
Number of pages7
JournalJournal of Immunology
Volume159
Issue number12
StatePublished - Dec 15 1997

ASJC Scopus subject areas

  • Immunology

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