SecB dependence of an exported protein is a continuum influenced by the characteristics of the signal peptide or early mature region

Jinoh Kim, Joen Luirink, Debra A. Kendall

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We have used Escherichia coli alkaline phosphatase to show the interplay among the characteristics of two amino-terminal domains in the preprotein (the signal peptide and the early mature region), the efficiency with which this protein is transported, and its requirement for SecB to accomplish the transport process. The results suggest that although alkaline phosphatase does not normally require SecB for transport, it is inherently able to utilize SecB, and it does so when its ability to interface with the transport machinery is compromised.

Original languageEnglish (US)
Pages (from-to)4108-4112
Number of pages5
JournalJournal of Bacteriology
Volume182
Issue number14
DOIs
StatePublished - Jul 2000
Externally publishedYes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

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