Sclerosing mesenteritis seen clinically as pancreatic pseudotumor

Two cases and a review

Rafiq A. Sheikh, Thomas P Prindiville, D. Arenson, B. H. Ruebner

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Sclerosing mesenteritis is an uncommon nonneoplastic inflammatory process in the mesentery that is seen as a pseudotumor, usually involving the small bowel mesentery, the mesenteric fat, and less commonly, the mesentery of the large bowel. We report two cases of sclerosing mesenteritis and review the literature on this rare disease. Both patients had pain, profound weight loss, and a mass on computed tomography (CT) scan of the abdomen. The provisional diagnosis was pancreatic neoplasm on the basis of clinical presentation and imaging studies. The diagnosis of sclerosing mesenteritis was established by histologic findings in biopsy material obtained at laparotomy in both cases. Interval histologic studies in one patient who had a high CA 19-9 level, progressive biliary ductal and partial duodenal compression, revealed a transitional histologic pattern from predominant inflammation and fat necrosis to predominant fibrosis. This may explain the varied descriptive terms used in the literature to describe this entity.

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalPancreas
Volume18
Issue number3
StatePublished - Apr 1999

Fingerprint

Peritoneal Panniculitis
Mesentery
Fat Necrosis
Rare Diseases
Pancreatic Neoplasms
Abdomen
Laparotomy
Weight Loss
Fibrosis
Fats
Tomography
Inflammation
Biopsy
Pain

Keywords

  • Pancreas
  • Pseudotumor
  • Sclerosing mesenteritis

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology

Cite this

Sclerosing mesenteritis seen clinically as pancreatic pseudotumor : Two cases and a review. / Sheikh, Rafiq A.; Prindiville, Thomas P; Arenson, D.; Ruebner, B. H.

In: Pancreas, Vol. 18, No. 3, 04.1999, p. 316-321.

Research output: Contribution to journalArticle

Sheikh, RA, Prindiville, TP, Arenson, D & Ruebner, BH 1999, 'Sclerosing mesenteritis seen clinically as pancreatic pseudotumor: Two cases and a review', Pancreas, vol. 18, no. 3, pp. 316-321.
Sheikh, Rafiq A. ; Prindiville, Thomas P ; Arenson, D. ; Ruebner, B. H. / Sclerosing mesenteritis seen clinically as pancreatic pseudotumor : Two cases and a review. In: Pancreas. 1999 ; Vol. 18, No. 3. pp. 316-321.
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