Abstract
In addition to epidemiologic studies suggesting a benefit for high intakes of α-tocopherol, studies following supplementation in humans have clearly shown that α-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with α-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 348-353 |
| Number of pages | 6 |
| Journal | Journal of Nutrition |
| Volume | 135 |
| Issue number | 2 |
| State | Published - Feb 2005 |
| Externally published | Yes |
Keywords
- α-tocopherol
- Antioxidant
- Cardiovascular disease
- Clinical trials
- Vitamin E
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
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Cite this
Jialal, I., & Devaraj, S. (2005). Scientific evidence to support a vitamin E and heart disease health claim: Research needs. Journal of Nutrition, 135(2), 348-353.