Abstract
In addition to epidemiologic studies suggesting a benefit for high intakes of α-tocopherol, studies following supplementation in humans have clearly shown that α-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with α-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 348-353 |
| Number of pages | 6 |
| Journal | Journal of Nutrition |
| Volume | 135 |
| Issue number | 2 |
| State | Published - Feb 2005 |
| Externally published | Yes |
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Keywords
- α-tocopherol
- Antioxidant
- Cardiovascular disease
- Clinical trials
- Vitamin E
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
Cite this
Scientific evidence to support a vitamin E and heart disease health claim : Research needs. / Jialal, I.; Devaraj, S.
In: Journal of Nutrition, Vol. 135, No. 2, 02.2005, p. 348-353.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Scientific evidence to support a vitamin E and heart disease health claim
T2 - Research needs
AU - Jialal, I.
AU - Devaraj, S.
PY - 2005/2
Y1 - 2005/2
N2 - In addition to epidemiologic studies suggesting a benefit for high intakes of α-tocopherol, studies following supplementation in humans have clearly shown that α-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with α-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.
AB - In addition to epidemiologic studies suggesting a benefit for high intakes of α-tocopherol, studies following supplementation in humans have clearly shown that α-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with α-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.
KW - α-tocopherol
KW - Antioxidant
KW - Cardiovascular disease
KW - Clinical trials
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=13244255227&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13244255227&partnerID=8YFLogxK
M3 - Article
C2 - 15671241
AN - SCOPUS:13244255227
VL - 135
SP - 348
EP - 353
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 2
ER -