Scientific evidence to support a vitamin E and heart disease health claim: Research needs

I. Jialal, S. Devaraj

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

In addition to epidemiologic studies suggesting a benefit for high intakes of α-tocopherol, studies following supplementation in humans have clearly shown that α-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with α-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.

Original languageEnglish (US)
Pages (from-to)348-353
Number of pages6
JournalJournal of Nutrition
Volume135
Issue number2
StatePublished - Feb 2005
Externally publishedYes

Keywords

  • α-tocopherol
  • Antioxidant
  • Cardiovascular disease
  • Clinical trials
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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