Scientific evidence to support a vitamin E and heart disease health claim: Research needs

I. Jialal, S. Devaraj

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

In addition to epidemiologic studies suggesting a benefit for high intakes of α-tocopherol, studies following supplementation in humans have clearly shown that α-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with α-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.

Original languageEnglish (US)
Pages (from-to)348-353
Number of pages6
JournalJournal of Nutrition
Volume135
Issue number2
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

health claims
Tocopherols
heart diseases
Vitamin E
tocopherols
vitamin E
Heart Diseases
clinical trials
Health
Research
Clinical Trials
anti-inflammatory agents
platelet aggregation
Platelet Aggregation
epidemiological studies
Lipid Peroxidation
Epidemiologic Studies
lipid peroxidation
Anti-Inflammatory Agents
Antioxidants

Keywords

  • α-tocopherol
  • Antioxidant
  • Cardiovascular disease
  • Clinical trials
  • Vitamin E

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Scientific evidence to support a vitamin E and heart disease health claim : Research needs. / Jialal, I.; Devaraj, S.

In: Journal of Nutrition, Vol. 135, No. 2, 02.2005, p. 348-353.

Research output: Contribution to journalArticle

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