Abstract
In addition to epidemiologic studies suggesting a benefit for high intakes of α-tocopherol, studies following supplementation in humans have clearly shown that α-tocopherol decreases lipid peroxidation, platelet aggregation, and functions as a potent anti-inflammatory agent. However, prospective human clinical trials with α-tocopherol alone and in combination with other antioxidants have been largely negative. In this review, we critically appraise the various clinical trials and provide recommendations for future research.
Original language | English (US) |
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Pages (from-to) | 348-353 |
Number of pages | 6 |
Journal | Journal of Nutrition |
Volume | 135 |
Issue number | 2 |
State | Published - Feb 2005 |
Externally published | Yes |
Keywords
- α-tocopherol
- Antioxidant
- Cardiovascular disease
- Clinical trials
- Vitamin E
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science