Schwann cell galactocerebroside of unmyelinated fibers is inducible by derivatives of adenosine 3′,5′-monophosphate

Gen Sobue, Takeshi Yasuda, Terunori Mitsuma, David E Pleasure

Research output: Contribution to journalArticle

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By using indirect immunofluorescence, galactocerebroside (galC) was detected on the surface of Schwann cells cultured from unmyelinated fibers of 10- to 12-day-old rat cervical sympathetic nerve trunk. By day 4 in vitro, galC-positive cells disappeared from the culture. When the 4-day cultures were treated with 1 mM 8-bromo cyclic AMP or dibutyryl cyclic AMP, galC reappeared in 72 h. The proportion of Schwann cells expressing galC was dependent on the concentration of cyclic AMP derivatives used.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalNeuroscience Letters
Issue number3
StatePublished - Dec 23 1986
Externally publishedYes



  • Adenosine 3′,5′-monophosphate derivative
  • Galactocerebroside
  • Schwann cell
  • Unmyelinated fiber

ASJC Scopus subject areas

  • Neuroscience(all)

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