Scanning interferometric near-infrared spectroscopy

Oybek Kholiqov, Wenjun Zhou, Tingwei Zhang, Mingjun Zhao, Soroush Ghandiparsi, Vivek J. Srinivasan

Research output: Contribution to journalArticlepeer-review


In diffuse optics, quantitative assessment of the human brain is confounded by the skull and scalp. To better understand these superficial tissues, we advance interferometric near-infrared spectroscopy (iNIRS) to form images of the human superficial forehead blood flow index (BFI). We present a null source–collector (S-C) polarization splitting approach that enables galvanometer scanning and eliminates unwanted backscattered light. Images show an order-of-magnitude heterogeneity in superficial dynamics, implying an order-of-magnitude heterogeneity in brain specificity, depending on forehead location. Along the time-of-flight dimension, autocorrelation decay rates support a three-layer model with increasing BFI from the skull to the scalp to the brain. By accurately characterizing superficial tissues, this approach can help improve specificity for the human brain.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalOptics Letters
Issue number1
StatePublished - Jan 1 2022

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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