Scaffolds for kidney tissue engineering

Alice F. Tarantal, Cynthia A. Batchelder

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is a worldwide burden of kidney disease and few organ donors to meet the transplant demand. The kidney is a highly complex organ with multiple cell types and functions; thus, it presents a significant challenge for repair. Applications for kidney tissue engineering include the use of three-dimensional (3D) organoids with pluripotent stem/progenitor cells, the natural extracellular matrix from the decellularized kidney, recellularization techniques using a range of cell populations, hydrogels, and synthetic matrices, and 3D bioprinting encompassing a layer-by-layer process with biomaterials and cells suspended in biological inks. Although many advances have been made, substantial challenges remain to meet the need to standardize protocols, efficiently recapitulate the architectural structure and function of the kidney, and conduct preclinical safety testing for translation to humans of all age groups.

Original languageEnglish (US)
Title of host publicationHandbook of Tissue Engineering Scaffolds
Subtitle of host publicationVolume Two
PublisherElsevier
Pages477-492
Number of pages16
ISBN (Electronic)9780081025611
ISBN (Print)9780081025628
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Bioprinting
  • Decellularization
  • Directed differentiation
  • Extracellular matrix
  • Kidney
  • Matrices
  • Pluripotent stem cells
  • Recellularization
  • Scaffolds
  • Tissue engineering

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)

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