Satiety-related hormonal dysregulation in behavioral variant frontotemporal dementia

Josh D. Woolley, Baber K. Khan, Alamelu Natesan, Anna Karydas, Mary Dallman, Peter J Havel, Bruce L. Miller, Katherine P. Rankin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To investigate whether patients with behavioral variant frontotemporal dementia (bvFTD) have dysregulation in satiety-related hormonal signaling using a laboratory-based case-control study. Methods: Fifty-four participants (19 patients with bvFTD, 17 patients with Alzheimer disease dementia, and 18 healthy normal controls [NCs]) were recruited from a tertiary-care dementia clinic. During a standardized breakfast, blood was drawn before, during, and after the breakfast protocol to quantify levels of peripheral satiety-related hormones (ghrelin, cortisol, insulin, leptin, and peptide YY) and glucose. To further explore the role of patients' feeding abnormalities on hormone levels, patients were classified into overeating and nonovereating subgroups based on feeding behavior during separate laboratory-based standardized lunch feeding sessions. Results: Irrespective of their feeding behavior in the laboratory, patients with bvFTD, but not patients with Alzheimer disease dementia, have significantly lower levels of ghrelin and cortisol and higher levels of insulin compared with NCs. Furthermore, while laboratory feeding behavior did not predict alterations in levels of ghrelin, cortisol, and insulin, only patients with bvFTD who significantly overate in the laboratory demonstrated significantly higher levels of leptin compared with NCs, suggesting that leptin may be sensitive to particularly severe feeding abnormalities in bvFTD. Conclusions: Despite a tendency to overeat, patients with bvFTD have a hormonal profile that should decrease food intake. Aberrant hormone levels may represent a compensatory response to the behavioral or neuroanatomical abnormalities of bvFTD.

Original languageEnglish (US)
Pages (from-to)512-520
Number of pages9
JournalNeurology
Volume82
Issue number6
DOIs
StatePublished - Feb 11 2014

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Frontotemporal Dementia
Ghrelin
Alzheimer Disease
Feeding Behavior
Leptin
Hydrocortisone
Breakfast
Hormones
Insulin
Peptide YY
Hyperphagia
Lunch
Tertiary Healthcare
Dementia
Case-Control Studies
Eating
Glucose

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Woolley, J. D., Khan, B. K., Natesan, A., Karydas, A., Dallman, M., Havel, P. J., ... Rankin, K. P. (2014). Satiety-related hormonal dysregulation in behavioral variant frontotemporal dementia. Neurology, 82(6), 512-520. https://doi.org/10.1212/WNL.0000000000000106

Satiety-related hormonal dysregulation in behavioral variant frontotemporal dementia. / Woolley, Josh D.; Khan, Baber K.; Natesan, Alamelu; Karydas, Anna; Dallman, Mary; Havel, Peter J; Miller, Bruce L.; Rankin, Katherine P.

In: Neurology, Vol. 82, No. 6, 11.02.2014, p. 512-520.

Research output: Contribution to journalArticle

Woolley, JD, Khan, BK, Natesan, A, Karydas, A, Dallman, M, Havel, PJ, Miller, BL & Rankin, KP 2014, 'Satiety-related hormonal dysregulation in behavioral variant frontotemporal dementia', Neurology, vol. 82, no. 6, pp. 512-520. https://doi.org/10.1212/WNL.0000000000000106
Woolley, Josh D. ; Khan, Baber K. ; Natesan, Alamelu ; Karydas, Anna ; Dallman, Mary ; Havel, Peter J ; Miller, Bruce L. ; Rankin, Katherine P. / Satiety-related hormonal dysregulation in behavioral variant frontotemporal dementia. In: Neurology. 2014 ; Vol. 82, No. 6. pp. 512-520.
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