Sarcoplasmic ionic calcium concentration in neuroleptic malignant syndrome

J. R. López, V. Sánchez, M. J. López

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The neuroleptic malignant syndrome (NMS) is an uncommon but serious adverse effect of antipsychotic medication. Similarities in the clinical picture, and muscle alterations, between NMS and susceptibility to malignant hyperthermia (MH) suggest common mechanisms underlying both disorders. Sarcoplasmic ionic calcium concentration ([Ca2+]i) was measured by means of Ca2+ selective microelectrodes in intact intercostal muscle fibers isolated from NMS patients and from subjects with no evidence of neuromuscular disease, who served as controls. The mean resting membrane potential and [Ca2+]i were -84 ± 0.4 mV and 0.11 ± 0.01 μM (mean ± SEM) in the control subjects, while they were -84± 0.6 mV and 0.51 ± 0.02 μM in NMS muscle fibers. Only the difference in [Ca2+]i is significant (P <0.001). The incubation of control and NMS muscle bundles in dantrolene (10-6M) induced a reduction of [Ca2+]i to 0.06 ± 0.01 μM and 0.20 ± 0.04 μM respectively. These results shown an alteration in sarcoplasmic ionic [Ca2+] in NMS muscle fibers, suggesting that a dysfunction in skeletal muscle plays some role in the pathogenesis of NMS.

Original languageEnglish (US)
Pages (from-to)223-233
Number of pages11
JournalCell Calcium
Volume10
Issue number4
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Neuroleptic Malignant Syndrome
Calcium
Muscles
Intercostal Muscles
Dantrolene
Malignant Hyperthermia
Neuromuscular Diseases
Microelectrodes
Membrane Potentials
Antipsychotic Agents
Skeletal Muscle

ASJC Scopus subject areas

  • Cell Biology
  • Endocrinology

Cite this

Sarcoplasmic ionic calcium concentration in neuroleptic malignant syndrome. / López, J. R.; Sánchez, V.; López, M. J.

In: Cell Calcium, Vol. 10, No. 4, 1989, p. 223-233.

Research output: Contribution to journalArticle

López, J. R. ; Sánchez, V. ; López, M. J. / Sarcoplasmic ionic calcium concentration in neuroleptic malignant syndrome. In: Cell Calcium. 1989 ; Vol. 10, No. 4. pp. 223-233.
@article{ab256884aa0944e1a0e22467bcf832b6,
title = "Sarcoplasmic ionic calcium concentration in neuroleptic malignant syndrome",
abstract = "The neuroleptic malignant syndrome (NMS) is an uncommon but serious adverse effect of antipsychotic medication. Similarities in the clinical picture, and muscle alterations, between NMS and susceptibility to malignant hyperthermia (MH) suggest common mechanisms underlying both disorders. Sarcoplasmic ionic calcium concentration ([Ca2+]i) was measured by means of Ca2+ selective microelectrodes in intact intercostal muscle fibers isolated from NMS patients and from subjects with no evidence of neuromuscular disease, who served as controls. The mean resting membrane potential and [Ca2+]i were -84 ± 0.4 mV and 0.11 ± 0.01 μM (mean ± SEM) in the control subjects, while they were -84± 0.6 mV and 0.51 ± 0.02 μM in NMS muscle fibers. Only the difference in [Ca2+]i is significant (P <0.001). The incubation of control and NMS muscle bundles in dantrolene (10-6M) induced a reduction of [Ca2+]i to 0.06 ± 0.01 μM and 0.20 ± 0.04 μM respectively. These results shown an alteration in sarcoplasmic ionic [Ca2+] in NMS muscle fibers, suggesting that a dysfunction in skeletal muscle plays some role in the pathogenesis of NMS.",
author = "L{\'o}pez, {J. R.} and V. S{\'a}nchez and L{\'o}pez, {M. J.}",
year = "1989",
doi = "10.1016/0143-4160(89)90005-5",
language = "English (US)",
volume = "10",
pages = "223--233",
journal = "Cell Calcium",
issn = "0143-4160",
publisher = "Churchill Livingstone",
number = "4",

}

TY - JOUR

T1 - Sarcoplasmic ionic calcium concentration in neuroleptic malignant syndrome

AU - López, J. R.

AU - Sánchez, V.

AU - López, M. J.

PY - 1989

Y1 - 1989

N2 - The neuroleptic malignant syndrome (NMS) is an uncommon but serious adverse effect of antipsychotic medication. Similarities in the clinical picture, and muscle alterations, between NMS and susceptibility to malignant hyperthermia (MH) suggest common mechanisms underlying both disorders. Sarcoplasmic ionic calcium concentration ([Ca2+]i) was measured by means of Ca2+ selective microelectrodes in intact intercostal muscle fibers isolated from NMS patients and from subjects with no evidence of neuromuscular disease, who served as controls. The mean resting membrane potential and [Ca2+]i were -84 ± 0.4 mV and 0.11 ± 0.01 μM (mean ± SEM) in the control subjects, while they were -84± 0.6 mV and 0.51 ± 0.02 μM in NMS muscle fibers. Only the difference in [Ca2+]i is significant (P <0.001). The incubation of control and NMS muscle bundles in dantrolene (10-6M) induced a reduction of [Ca2+]i to 0.06 ± 0.01 μM and 0.20 ± 0.04 μM respectively. These results shown an alteration in sarcoplasmic ionic [Ca2+] in NMS muscle fibers, suggesting that a dysfunction in skeletal muscle plays some role in the pathogenesis of NMS.

AB - The neuroleptic malignant syndrome (NMS) is an uncommon but serious adverse effect of antipsychotic medication. Similarities in the clinical picture, and muscle alterations, between NMS and susceptibility to malignant hyperthermia (MH) suggest common mechanisms underlying both disorders. Sarcoplasmic ionic calcium concentration ([Ca2+]i) was measured by means of Ca2+ selective microelectrodes in intact intercostal muscle fibers isolated from NMS patients and from subjects with no evidence of neuromuscular disease, who served as controls. The mean resting membrane potential and [Ca2+]i were -84 ± 0.4 mV and 0.11 ± 0.01 μM (mean ± SEM) in the control subjects, while they were -84± 0.6 mV and 0.51 ± 0.02 μM in NMS muscle fibers. Only the difference in [Ca2+]i is significant (P <0.001). The incubation of control and NMS muscle bundles in dantrolene (10-6M) induced a reduction of [Ca2+]i to 0.06 ± 0.01 μM and 0.20 ± 0.04 μM respectively. These results shown an alteration in sarcoplasmic ionic [Ca2+] in NMS muscle fibers, suggesting that a dysfunction in skeletal muscle plays some role in the pathogenesis of NMS.

UR - http://www.scopus.com/inward/record.url?scp=0024390618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024390618&partnerID=8YFLogxK

U2 - 10.1016/0143-4160(89)90005-5

DO - 10.1016/0143-4160(89)90005-5

M3 - Article

VL - 10

SP - 223

EP - 233

JO - Cell Calcium

JF - Cell Calcium

SN - 0143-4160

IS - 4

ER -