Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise?

Matthew R. Kappus, Mardeli Saire Mendoza, Douglas Nguyen, Valentina Medici, Stephen A. McClave

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Sarcopenia, a loss of muscle mass, is being increasingly recognized to have a deleterious effect on outcomes in patients with chronic liver disease. Factors related to diet and the inflammatory nature of chronic liver disease contribute to the occurrence of sarcopenia in these patients. Sarcopenia adversely influences quality of life, performance, morbidity, success of transplantation, and even mortality. Specific deficiencies in macronutrients (protein, polyunsaturated fatty acids) and micronutrients (vitamins C, D, and E, carotenoids, and selenium) have been linked to sarcopenia. Lessons learned from nutritional therapy in geriatric patient populations may provide strategies to manage sarcopenia in patients with liver disease. Combining diet modification and nutrient supplementation with an organized program of exercise may help ameliorate or even reverse the effects of sarcopenia on an already complex disease process.

Original languageEnglish (US)
Article number43
JournalCurrent Gastroenterology Reports
Volume18
Issue number8
DOIs
StatePublished - Aug 1 2016

Fingerprint

Sarcopenia
Liver Diseases
Chronic Disease
Exercise
Diet
Diet Therapy
Micronutrients
Carotenoids
Selenium
Unsaturated Fatty Acids
Vitamin E
Vitamin D
Geriatrics
Ascorbic Acid
Transplantation
Quality of Life
Morbidity
Food
Muscles
Mortality

Keywords

  • Cirrhosis
  • Liver disease
  • Malnutrition
  • Muscle wasting
  • Portal hypertension
  • Protein malnutrition
  • Sarcopenia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Sarcopenia in Patients with Chronic Liver Disease : Can It Be Altered by Diet and Exercise? / Kappus, Matthew R.; Mendoza, Mardeli Saire; Nguyen, Douglas; Medici, Valentina; McClave, Stephen A.

In: Current Gastroenterology Reports, Vol. 18, No. 8, 43, 01.08.2016.

Research output: Contribution to journalReview article

Kappus, Matthew R. ; Mendoza, Mardeli Saire ; Nguyen, Douglas ; Medici, Valentina ; McClave, Stephen A. / Sarcopenia in Patients with Chronic Liver Disease : Can It Be Altered by Diet and Exercise?. In: Current Gastroenterology Reports. 2016 ; Vol. 18, No. 8.
@article{03e2c2d85e03447290a5e277ff0ed828,
title = "Sarcopenia in Patients with Chronic Liver Disease: Can It Be Altered by Diet and Exercise?",
abstract = "Sarcopenia, a loss of muscle mass, is being increasingly recognized to have a deleterious effect on outcomes in patients with chronic liver disease. Factors related to diet and the inflammatory nature of chronic liver disease contribute to the occurrence of sarcopenia in these patients. Sarcopenia adversely influences quality of life, performance, morbidity, success of transplantation, and even mortality. Specific deficiencies in macronutrients (protein, polyunsaturated fatty acids) and micronutrients (vitamins C, D, and E, carotenoids, and selenium) have been linked to sarcopenia. Lessons learned from nutritional therapy in geriatric patient populations may provide strategies to manage sarcopenia in patients with liver disease. Combining diet modification and nutrient supplementation with an organized program of exercise may help ameliorate or even reverse the effects of sarcopenia on an already complex disease process.",
keywords = "Cirrhosis, Liver disease, Malnutrition, Muscle wasting, Portal hypertension, Protein malnutrition, Sarcopenia",
author = "Kappus, {Matthew R.} and Mendoza, {Mardeli Saire} and Douglas Nguyen and Valentina Medici and McClave, {Stephen A.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1007/s11894-016-0516-y",
language = "English (US)",
volume = "18",
journal = "Current Gastroenterology Reports",
issn = "1522-8037",
publisher = "Current Medicine Group",
number = "8",

}

TY - JOUR

T1 - Sarcopenia in Patients with Chronic Liver Disease

T2 - Can It Be Altered by Diet and Exercise?

AU - Kappus, Matthew R.

AU - Mendoza, Mardeli Saire

AU - Nguyen, Douglas

AU - Medici, Valentina

AU - McClave, Stephen A.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Sarcopenia, a loss of muscle mass, is being increasingly recognized to have a deleterious effect on outcomes in patients with chronic liver disease. Factors related to diet and the inflammatory nature of chronic liver disease contribute to the occurrence of sarcopenia in these patients. Sarcopenia adversely influences quality of life, performance, morbidity, success of transplantation, and even mortality. Specific deficiencies in macronutrients (protein, polyunsaturated fatty acids) and micronutrients (vitamins C, D, and E, carotenoids, and selenium) have been linked to sarcopenia. Lessons learned from nutritional therapy in geriatric patient populations may provide strategies to manage sarcopenia in patients with liver disease. Combining diet modification and nutrient supplementation with an organized program of exercise may help ameliorate or even reverse the effects of sarcopenia on an already complex disease process.

AB - Sarcopenia, a loss of muscle mass, is being increasingly recognized to have a deleterious effect on outcomes in patients with chronic liver disease. Factors related to diet and the inflammatory nature of chronic liver disease contribute to the occurrence of sarcopenia in these patients. Sarcopenia adversely influences quality of life, performance, morbidity, success of transplantation, and even mortality. Specific deficiencies in macronutrients (protein, polyunsaturated fatty acids) and micronutrients (vitamins C, D, and E, carotenoids, and selenium) have been linked to sarcopenia. Lessons learned from nutritional therapy in geriatric patient populations may provide strategies to manage sarcopenia in patients with liver disease. Combining diet modification and nutrient supplementation with an organized program of exercise may help ameliorate or even reverse the effects of sarcopenia on an already complex disease process.

KW - Cirrhosis

KW - Liver disease

KW - Malnutrition

KW - Muscle wasting

KW - Portal hypertension

KW - Protein malnutrition

KW - Sarcopenia

UR - http://www.scopus.com/inward/record.url?scp=84977117577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84977117577&partnerID=8YFLogxK

U2 - 10.1007/s11894-016-0516-y

DO - 10.1007/s11894-016-0516-y

M3 - Review article

C2 - 27372291

AN - SCOPUS:84977117577

VL - 18

JO - Current Gastroenterology Reports

JF - Current Gastroenterology Reports

SN - 1522-8037

IS - 8

M1 - 43

ER -