Sarcopenia among patients receiving hemodialysis

Weighing the evidence

Piyawan Kittiskulnam, Juan J. Carrero, Glenn M. Chertow, George Kaysen, Cynthia Delgado, Kirsten L. Johansen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: There is no consensus on how best to define low muscle mass in patients with end-stage renal disease. Use of muscle mass normalized to height-squared has been suggested by geriatric societies but may underestimate sarcopenia, particularly in the setting of excess adiposity. We compared four definitions of low muscle mass in a prevalent hemodialysis cohort. Methods: ACTIVE/ADIPOSE enrolled prevalent patients receiving hemodialysis from the San Francisco and Atlanta areas from June 2009 to August 2011. Whole-body muscle mass was estimated using bioelectrical impedance spectroscopy, performed before a midweek dialysis session (n=645; age 56.7±14.5years, 41% women). We defined low muscle mass as muscle mass of 2SD or more below sex-specific bioelectrical impedance spectroscopy-derived means for young adults (18-49years) from National Health and Nutrition Examination Survey and indexed to height2, body weight (percentage), body surface area (BSA) by the DuBois formula, or Quételet's body mass index (BMI). We compared prevalence of low muscle mass among the four methods and assessed their correlation with strength and physical performance. Results: The prevalence of low muscle mass ranged from 8 to 32%. Muscle mass indexed to height2 classified the smallest percentage of patients as having low muscle mass, particularly among women, whereas indexing by BSA classified the largest percentage. Low muscle mass/height2 was present almost exclusively among normal or underweight patients, whereas indexing to body weight and BMI classified more overweight and obese patients as having low muscle mass. Handgrip strength was lower among those with low muscle mass by all methods except height2. Handgrip strength was directly and modestly correlated with muscle mass normalized by percentage of body weight, BSA, and BMI (ρ=0.43, 0.56, and, 0.64, respectively) and less so with muscle/height2 (ρ=0.31, P<0.001). The difference in grip strength among patients with low vs. normal muscle mass was largest according to muscle/BMI (-6.84kg, 95% CI -8.66 to -5.02, P<0.001). There were significant direct correlations of gait speed with muscle mass indexed to percentage of body weight, BSA, and BMI but not with muscle mass indexed to height2. Conclusions: Skeletal muscle mass normalized to height2 may underestimate the prevalence of low muscle mass, particularly among overweight and obese patients on hemodialysis. Valid detection of sarcopenia among obese patients receiving hemodialysis requires adjustment for body size.

Original languageEnglish (US)
JournalJournal of Cachexia, Sarcopenia and Muscle
DOIs
StateAccepted/In press - 2016

Fingerprint

Sarcopenia
Renal Dialysis
Muscles
Body Surface Area
Body Mass Index
Body Weight
Dielectric Spectroscopy
Electric Impedance

Keywords

  • Gait speed
  • Handgrip strength
  • Hemodialysis
  • Low muscle mass
  • Sarcopenia

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physiology (medical)

Cite this

Kittiskulnam, P., Carrero, J. J., Chertow, G. M., Kaysen, G., Delgado, C., & Johansen, K. L. (Accepted/In press). Sarcopenia among patients receiving hemodialysis: Weighing the evidence. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.12130

Sarcopenia among patients receiving hemodialysis : Weighing the evidence. / Kittiskulnam, Piyawan; Carrero, Juan J.; Chertow, Glenn M.; Kaysen, George; Delgado, Cynthia; Johansen, Kirsten L.

In: Journal of Cachexia, Sarcopenia and Muscle, 2016.

Research output: Contribution to journalArticle

Kittiskulnam, Piyawan ; Carrero, Juan J. ; Chertow, Glenn M. ; Kaysen, George ; Delgado, Cynthia ; Johansen, Kirsten L. / Sarcopenia among patients receiving hemodialysis : Weighing the evidence. In: Journal of Cachexia, Sarcopenia and Muscle. 2016.
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abstract = "Background: There is no consensus on how best to define low muscle mass in patients with end-stage renal disease. Use of muscle mass normalized to height-squared has been suggested by geriatric societies but may underestimate sarcopenia, particularly in the setting of excess adiposity. We compared four definitions of low muscle mass in a prevalent hemodialysis cohort. Methods: ACTIVE/ADIPOSE enrolled prevalent patients receiving hemodialysis from the San Francisco and Atlanta areas from June 2009 to August 2011. Whole-body muscle mass was estimated using bioelectrical impedance spectroscopy, performed before a midweek dialysis session (n=645; age 56.7±14.5years, 41{\%} women). We defined low muscle mass as muscle mass of 2SD or more below sex-specific bioelectrical impedance spectroscopy-derived means for young adults (18-49years) from National Health and Nutrition Examination Survey and indexed to height2, body weight (percentage), body surface area (BSA) by the DuBois formula, or Qu{\'e}telet's body mass index (BMI). We compared prevalence of low muscle mass among the four methods and assessed their correlation with strength and physical performance. Results: The prevalence of low muscle mass ranged from 8 to 32{\%}. Muscle mass indexed to height2 classified the smallest percentage of patients as having low muscle mass, particularly among women, whereas indexing by BSA classified the largest percentage. Low muscle mass/height2 was present almost exclusively among normal or underweight patients, whereas indexing to body weight and BMI classified more overweight and obese patients as having low muscle mass. Handgrip strength was lower among those with low muscle mass by all methods except height2. Handgrip strength was directly and modestly correlated with muscle mass normalized by percentage of body weight, BSA, and BMI (ρ=0.43, 0.56, and, 0.64, respectively) and less so with muscle/height2 (ρ=0.31, P<0.001). The difference in grip strength among patients with low vs. normal muscle mass was largest according to muscle/BMI (-6.84kg, 95{\%} CI -8.66 to -5.02, P<0.001). There were significant direct correlations of gait speed with muscle mass indexed to percentage of body weight, BSA, and BMI but not with muscle mass indexed to height2. Conclusions: Skeletal muscle mass normalized to height2 may underestimate the prevalence of low muscle mass, particularly among overweight and obese patients on hemodialysis. Valid detection of sarcopenia among obese patients receiving hemodialysis requires adjustment for body size.",
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N2 - Background: There is no consensus on how best to define low muscle mass in patients with end-stage renal disease. Use of muscle mass normalized to height-squared has been suggested by geriatric societies but may underestimate sarcopenia, particularly in the setting of excess adiposity. We compared four definitions of low muscle mass in a prevalent hemodialysis cohort. Methods: ACTIVE/ADIPOSE enrolled prevalent patients receiving hemodialysis from the San Francisco and Atlanta areas from June 2009 to August 2011. Whole-body muscle mass was estimated using bioelectrical impedance spectroscopy, performed before a midweek dialysis session (n=645; age 56.7±14.5years, 41% women). We defined low muscle mass as muscle mass of 2SD or more below sex-specific bioelectrical impedance spectroscopy-derived means for young adults (18-49years) from National Health and Nutrition Examination Survey and indexed to height2, body weight (percentage), body surface area (BSA) by the DuBois formula, or Quételet's body mass index (BMI). We compared prevalence of low muscle mass among the four methods and assessed their correlation with strength and physical performance. Results: The prevalence of low muscle mass ranged from 8 to 32%. Muscle mass indexed to height2 classified the smallest percentage of patients as having low muscle mass, particularly among women, whereas indexing by BSA classified the largest percentage. Low muscle mass/height2 was present almost exclusively among normal or underweight patients, whereas indexing to body weight and BMI classified more overweight and obese patients as having low muscle mass. Handgrip strength was lower among those with low muscle mass by all methods except height2. Handgrip strength was directly and modestly correlated with muscle mass normalized by percentage of body weight, BSA, and BMI (ρ=0.43, 0.56, and, 0.64, respectively) and less so with muscle/height2 (ρ=0.31, P<0.001). The difference in grip strength among patients with low vs. normal muscle mass was largest according to muscle/BMI (-6.84kg, 95% CI -8.66 to -5.02, P<0.001). There were significant direct correlations of gait speed with muscle mass indexed to percentage of body weight, BSA, and BMI but not with muscle mass indexed to height2. Conclusions: Skeletal muscle mass normalized to height2 may underestimate the prevalence of low muscle mass, particularly among overweight and obese patients on hemodialysis. Valid detection of sarcopenia among obese patients receiving hemodialysis requires adjustment for body size.

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