Sampling the fetoplacental circulation. III. Combined laparoscopy-fetoscopy in the pregnant macaque for hemoglobin identification

Ezra C. Davidson, John A. Morris, John P. O'Grady, Andrew G Hendrickx, John Anderson, Michael Kaback, Robert Frazer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To demonstrate increased technical experience with fetoscopy and fetal blood sampling, two groups of macaques were compared to control animals. Group 2 had a perinatal mortality rate that was not significantly different from that of the control group. A 2.7 mm. Hopkins rod lens endoscope encased in an eccentric cannula, 3.8 mm. outside diameter, was used. When compared to the earlier test group (Group 1), the later test group (Group 2) showed greater adequacy of the fetal blood sample for laboratory analysis (P < 0.01). Anthropometric and hematologic data collected at term births compared favorably in test and control groups, with the exception of the white blood cell count, which was significantly lower with fetoscopy (P < 0.01). This is the first report of experimental fetoscopy with the use of a control group to provide precise data to aid in clarification of the ethical issues yet unresolved in this technology.

Original languageEnglish (US)
Pages (from-to)833-841
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume132
Issue number8
StatePublished - Dec 15 1978

Fingerprint

Fetoscopy
Placental Circulation
Macaca
Laparoscopy
Hemoglobins
Fetal Blood
Control Groups
Term Birth
Endoscopes
Perinatal Mortality
Leukocyte Count
Ethics
Lenses
Technology
Mortality

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Davidson, E. C., Morris, J. A., O'Grady, J. P., Hendrickx, A. G., Anderson, J., Kaback, M., & Frazer, R. (1978). Sampling the fetoplacental circulation. III. Combined laparoscopy-fetoscopy in the pregnant macaque for hemoglobin identification. American Journal of Obstetrics and Gynecology, 132(8), 833-841.

Sampling the fetoplacental circulation. III. Combined laparoscopy-fetoscopy in the pregnant macaque for hemoglobin identification. / Davidson, Ezra C.; Morris, John A.; O'Grady, John P.; Hendrickx, Andrew G; Anderson, John; Kaback, Michael; Frazer, Robert.

In: American Journal of Obstetrics and Gynecology, Vol. 132, No. 8, 15.12.1978, p. 833-841.

Research output: Contribution to journalArticle

Davidson, EC, Morris, JA, O'Grady, JP, Hendrickx, AG, Anderson, J, Kaback, M & Frazer, R 1978, 'Sampling the fetoplacental circulation. III. Combined laparoscopy-fetoscopy in the pregnant macaque for hemoglobin identification', American Journal of Obstetrics and Gynecology, vol. 132, no. 8, pp. 833-841.
Davidson, Ezra C. ; Morris, John A. ; O'Grady, John P. ; Hendrickx, Andrew G ; Anderson, John ; Kaback, Michael ; Frazer, Robert. / Sampling the fetoplacental circulation. III. Combined laparoscopy-fetoscopy in the pregnant macaque for hemoglobin identification. In: American Journal of Obstetrics and Gynecology. 1978 ; Vol. 132, No. 8. pp. 833-841.
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