Abstract
To demonstrate increased technical experience with fetoscopy and fetal blood sampling, two groups of macaques were compared to control animals. Group 2 had a perinatal mortality rate that was not significantly different from that of the control group. A 2.7 mm. Hopkins rod lens endoscope encased in an eccentric cannula, 3.8 mm. outside diameter, was used. When compared to the earlier test group (Group 1), the later test group (Group 2) showed greater adequacy of the fetal blood sample for laboratory analysis (P < 0.01). Anthropometric and hematologic data collected at term births compared favorably in test and control groups, with the exception of the white blood cell count, which was significantly lower with fetoscopy (P < 0.01). This is the first report of experimental fetoscopy with the use of a control group to provide precise data to aid in clarification of the ethical issues yet unresolved in this technology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 833-841 |
| Number of pages | 9 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 132 |
| Issue number | 8 |
| State | Published - Dec 15 1978 |
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ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
Sampling the fetoplacental circulation. III. Combined laparoscopy-fetoscopy in the pregnant macaque for hemoglobin identification. / Davidson, Ezra C.; Morris, John A.; O'Grady, John P.; Hendrickx, Andrew G; Anderson, John; Kaback, Michael; Frazer, Robert.
In: American Journal of Obstetrics and Gynecology, Vol. 132, No. 8, 15.12.1978, p. 833-841.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sampling the fetoplacental circulation. III. Combined laparoscopy-fetoscopy in the pregnant macaque for hemoglobin identification
AU - Davidson, Ezra C.
AU - Morris, John A.
AU - O'Grady, John P.
AU - Hendrickx, Andrew G
AU - Anderson, John
AU - Kaback, Michael
AU - Frazer, Robert
PY - 1978/12/15
Y1 - 1978/12/15
N2 - To demonstrate increased technical experience with fetoscopy and fetal blood sampling, two groups of macaques were compared to control animals. Group 2 had a perinatal mortality rate that was not significantly different from that of the control group. A 2.7 mm. Hopkins rod lens endoscope encased in an eccentric cannula, 3.8 mm. outside diameter, was used. When compared to the earlier test group (Group 1), the later test group (Group 2) showed greater adequacy of the fetal blood sample for laboratory analysis (P < 0.01). Anthropometric and hematologic data collected at term births compared favorably in test and control groups, with the exception of the white blood cell count, which was significantly lower with fetoscopy (P < 0.01). This is the first report of experimental fetoscopy with the use of a control group to provide precise data to aid in clarification of the ethical issues yet unresolved in this technology.
AB - To demonstrate increased technical experience with fetoscopy and fetal blood sampling, two groups of macaques were compared to control animals. Group 2 had a perinatal mortality rate that was not significantly different from that of the control group. A 2.7 mm. Hopkins rod lens endoscope encased in an eccentric cannula, 3.8 mm. outside diameter, was used. When compared to the earlier test group (Group 1), the later test group (Group 2) showed greater adequacy of the fetal blood sample for laboratory analysis (P < 0.01). Anthropometric and hematologic data collected at term births compared favorably in test and control groups, with the exception of the white blood cell count, which was significantly lower with fetoscopy (P < 0.01). This is the first report of experimental fetoscopy with the use of a control group to provide precise data to aid in clarification of the ethical issues yet unresolved in this technology.
UR - http://www.scopus.com/inward/record.url?scp=0018164968&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018164968&partnerID=8YFLogxK
M3 - Article
C2 - 153713
AN - SCOPUS:0018164968
VL - 132
SP - 833
EP - 841
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 8
ER -