Sample size determination for estimation of the accuracy of two conditionally independent tests in the absence of a gold standard

Marios P. Georgiadis, Wesley O. Johnson, Ian Gardner

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We developed an Excel spreadsheet template (available at http://www.epi.ucdavis.edu/diagnostictests/) to calculate sample sizes to estimate sensitivity and specificity with desired precision in the absence of a gold standard. Calculations are predicated on the use of two conditionally independent tests for screening animals from two populations and are based on the methods of Hui and Walter (1980). Sample size calculations rely on asymptotic normality of maximum likelihood (ML) estimates of parameters. Spreadsheets for calculating standard errors for the parameter estimates and for providing ML estimates using cross-tabulated data also are included. An example of application of the methods to bovine paratuberculosis is presented.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalPreventive Veterinary Medicine
Volume71
Issue number1-2
DOIs
StatePublished - Sep 30 2005

Keywords

  • Hui and Walter model
  • Prevalence
  • Sample size
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology

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