Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA

Paul Henderson, Mark D. Evans, Marcus S. Cooke

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume703
Issue number1
DOIs
StatePublished - Nov 28 2010

Keywords

  • 8-oxodG
  • Accelerator mass Spectrometry
  • DNA repair
  • Nucleotide pool oxidation
  • Salvage

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Genetics

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