Salt, starch, and water on the brain

R. M. Schell, Richard Lee Applegate, D. J. Cole

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


Isotonic fluids have been thoroughly studied and for the vast majority of neurosurgical patients are both safe and effective. Conversely, HS may have some transient beneficial effects on cerebral physiology in animal models of brain injury. However, further studies are needed to measure the functional outcome rather than early parameters of CNS function with HS resuscitation. In addition, HS has a defined risk. Until the risk-benefit ratio of HS is better defined in humans, physicians should exercise caution and adhere to the Hippocratic oath. However, if this risk-benefit ratio is defined, HS may hold promise for the clinical conditions cited herein as well as other novel uses (cardiopulmonary bypass, spinal trauma [55,56]).

Original languageEnglish (US)
Pages (from-to)178-182
Number of pages5
JournalJournal of Neurosurgical Anesthesiology
Issue number2
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology


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