Salmonella typhimurium mutants lacking NAD pyrophosphatase

U. E. Park, J. R. Roth, B. M. Olivera

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

NAD can serve as both a purine and a pyridine source for Salmonella typhimurium. Exogenous NAD is rapidly broken down into nicotinamide mononucleotide and AMP by an NAD pyrophosphatase, the first step in the pathway for the assimilation of exogenous NAD. We isolated and characterized mutants of S. typhimurium lacking NAD pyrophosphatase activity; such mutants were identified by their failure to use exogenous NAD as a purine source. These mutants carry mutations that map at a new locus, designated pnuE, between 86 and 87 min on the Salmonella chromosome.

Original languageEnglish (US)
Pages (from-to)3725-3730
Number of pages6
JournalJournal of Bacteriology
Volume170
Issue number8
StatePublished - 1988
Externally publishedYes

Fingerprint

Salmonella typhimurium
NAD
Nicotinamide Mononucleotide
Adenosine Monophosphate
Salmonella
Chromosomes
Mutation
NAD pyrophosphatase
purine

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology

Cite this

Park, U. E., Roth, J. R., & Olivera, B. M. (1988). Salmonella typhimurium mutants lacking NAD pyrophosphatase. Journal of Bacteriology, 170(8), 3725-3730.

Salmonella typhimurium mutants lacking NAD pyrophosphatase. / Park, U. E.; Roth, J. R.; Olivera, B. M.

In: Journal of Bacteriology, Vol. 170, No. 8, 1988, p. 3725-3730.

Research output: Contribution to journalArticle

Park, UE, Roth, JR & Olivera, BM 1988, 'Salmonella typhimurium mutants lacking NAD pyrophosphatase', Journal of Bacteriology, vol. 170, no. 8, pp. 3725-3730.
Park UE, Roth JR, Olivera BM. Salmonella typhimurium mutants lacking NAD pyrophosphatase. Journal of Bacteriology. 1988;170(8):3725-3730.
Park, U. E. ; Roth, J. R. ; Olivera, B. M. / Salmonella typhimurium mutants lacking NAD pyrophosphatase. In: Journal of Bacteriology. 1988 ; Vol. 170, No. 8. pp. 3725-3730.
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