Salmonella typhimurium mutants lacking NAD pyrophosphatase

U. E. Park; J. R. Roth; B. M. Olivera

Salmonella typhimurium mutants lacking NAD pyrophosphatase

U. E. Park, J. R. Roth, B. M. Olivera

Research output: Contribution to journal › Article › peer-review

Abstract

NAD can serve as both a purine and a pyridine source for Salmonella typhimurium. Exogenous NAD is rapidly broken down into nicotinamide mononucleotide and AMP by an NAD pyrophosphatase, the first step in the pathway for the assimilation of exogenous NAD. We isolated and characterized mutants of S. typhimurium lacking NAD pyrophosphatase activity; such mutants were identified by their failure to use exogenous NAD as a purine source. These mutants carry mutations that map at a new locus, designated pnuE, between 86 and 87 min on the Salmonella chromosome.

Original language	English (US)
Pages (from-to)	3725-3730
Number of pages	6
Journal	Journal of Bacteriology
Volume	170
Issue number	8
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Immunology

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abstract = "NAD can serve as both a purine and a pyridine source for Salmonella typhimurium. Exogenous NAD is rapidly broken down into nicotinamide mononucleotide and AMP by an NAD pyrophosphatase, the first step in the pathway for the assimilation of exogenous NAD. We isolated and characterized mutants of S. typhimurium lacking NAD pyrophosphatase activity; such mutants were identified by their failure to use exogenous NAD as a purine source. These mutants carry mutations that map at a new locus, designated pnuE, between 86 and 87 min on the Salmonella chromosome.",

author = "Park, {U. E.} and Roth, {J. R.} and Olivera, {B. M.}",

year = "1988",

language = "English (US)",

volume = "170",

pages = "3725--3730",

journal = "Journal of Bacteriology",

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publisher = "American Society for Microbiology",

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T1 - Salmonella typhimurium mutants lacking NAD pyrophosphatase

AU - Park, U. E.

AU - Roth, J. R.

AU - Olivera, B. M.

PY - 1988

Y1 - 1988

N2 - NAD can serve as both a purine and a pyridine source for Salmonella typhimurium. Exogenous NAD is rapidly broken down into nicotinamide mononucleotide and AMP by an NAD pyrophosphatase, the first step in the pathway for the assimilation of exogenous NAD. We isolated and characterized mutants of S. typhimurium lacking NAD pyrophosphatase activity; such mutants were identified by their failure to use exogenous NAD as a purine source. These mutants carry mutations that map at a new locus, designated pnuE, between 86 and 87 min on the Salmonella chromosome.

AB - NAD can serve as both a purine and a pyridine source for Salmonella typhimurium. Exogenous NAD is rapidly broken down into nicotinamide mononucleotide and AMP by an NAD pyrophosphatase, the first step in the pathway for the assimilation of exogenous NAD. We isolated and characterized mutants of S. typhimurium lacking NAD pyrophosphatase activity; such mutants were identified by their failure to use exogenous NAD as a purine source. These mutants carry mutations that map at a new locus, designated pnuE, between 86 and 87 min on the Salmonella chromosome.

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JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

IS - 8

ER -

Salmonella typhimurium mutants lacking NAD pyrophosphatase

Abstract

ASJC Scopus subject areas

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