Salmonella flagellin, a microbial target of the innate and adaptive immune system

Rosa Maria Salazar-Gonzalez, Stephen J Mcsorley

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalImmunology Letters
Volume101
Issue number2
DOIs
StatePublished - Nov 15 2005
Externally publishedYes

Keywords

  • Flagellin
  • Innate immunity
  • Salmonella

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Fingerprint Dive into the research topics of 'Salmonella flagellin, a microbial target of the innate and adaptive immune system'. Together they form a unique fingerprint.

  • Cite this