Salmonella flagellin, a microbial target of the innate and adaptive immune system

Rosa Maria Salazar-Gonzalez; Stephen J Mcsorley

doi:10.1016/j.imlet.2005.05.004

Salmonella flagellin, a microbial target of the innate and adaptive immune system

Rosa Maria Salazar-Gonzalez, Stephen J Mcsorley

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.

Original language	English (US)
Pages (from-to)	117-122
Number of pages	6
Journal	Immunology Letters
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/j.imlet.2005.05.004
State	Published - Nov 15 2005
Externally published	Yes

Keywords

Flagellin
Innate immunity
Salmonella

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.imlet.2005.05.004

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abstract = "Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.",

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AU - Mcsorley, Stephen J

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AB - Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.

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KW - Innate immunity

KW - Salmonella

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Salmonella flagellin, a microbial target of the innate and adaptive immune system

Abstract

Keywords

ASJC Scopus subject areas

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