Abstract
Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-122 |
| Number of pages | 6 |
| Journal | Immunology Letters |
| Volume | 101 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 15 2005 |
| Externally published | Yes |
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Keywords
- Flagellin
- Innate immunity
- Salmonella
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Salmonella flagellin, a microbial target of the innate and adaptive immune system. / Salazar-Gonzalez, Rosa Maria; Mcsorley, Stephen J.
In: Immunology Letters, Vol. 101, No. 2, 15.11.2005, p. 117-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Salmonella flagellin, a microbial target of the innate and adaptive immune system
AU - Salazar-Gonzalez, Rosa Maria
AU - Mcsorley, Stephen J
PY - 2005/11/15
Y1 - 2005/11/15
N2 - Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.
AB - Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.
KW - Flagellin
KW - Innate immunity
KW - Salmonella
UR - http://www.scopus.com/inward/record.url?scp=25444453726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=25444453726&partnerID=8YFLogxK
U2 - 10.1016/j.imlet.2005.05.004
DO - 10.1016/j.imlet.2005.05.004
M3 - Article
C2 - 15975666
AN - SCOPUS:25444453726
VL - 101
SP - 117
EP - 122
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 2
ER -