Salmonella flagellin, a microbial target of the innate and adaptive immune system

Rosa Maria Salazar-Gonzalez, Stephen J Mcsorley

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalImmunology Letters
Volume101
Issue number2
DOIs
StatePublished - Nov 15 2005
Externally publishedYes

Fingerprint

Flagellin
Salmonella
Immune System
Salmonella Infections
Adaptive Immunity
Innate Immunity
Dendritic Cells
Autoimmune Diseases
T-Lymphocytes
Antibodies
Infection
Proteins

Keywords

  • Flagellin
  • Innate immunity
  • Salmonella

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Salmonella flagellin, a microbial target of the innate and adaptive immune system. / Salazar-Gonzalez, Rosa Maria; Mcsorley, Stephen J.

In: Immunology Letters, Vol. 101, No. 2, 15.11.2005, p. 117-122.

Research output: Contribution to journalArticle

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