Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities

Takeo Kasagami, In Hae Kim, Hsing Ju Tsai, Kosuke Nishi, Bruce D. Hammock, Christophe Morisseau

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We investigated N-adamantyl-N′-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.

Original languageEnglish (US)
Pages (from-to)1784-1789
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number6
DOIs
StatePublished - Mar 15 2009

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Keywords

  • Anti-inflammation
  • Hypertension
  • Intramolecular hydrogen bond
  • Metabolic and chemical stability
  • Salicylate
  • Soluble epoxide hydrolase
  • Urea

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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