Abstract
We investigated N-adamantyl-N′-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.
Original language | English (US) |
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Pages (from-to) | 1784-1789 |
Number of pages | 6 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2009 |
Keywords
- Anti-inflammation
- Hypertension
- Intramolecular hydrogen bond
- Metabolic and chemical stability
- Salicylate
- Soluble epoxide hydrolase
- Urea
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry
- Biochemistry