Abstract
We investigated N-adamantyl-N′-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1784-1789 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 15 2009 |
Keywords
- Anti-inflammation
- Hypertension
- Intramolecular hydrogen bond
- Metabolic and chemical stability
- Salicylate
- Soluble epoxide hydrolase
- Urea
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry
- Biochemistry
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Cite this
Kasagami, T., Kim, I. H., Tsai, H. J., Nishi, K., Hammock, B. D., & Morisseau, C. (2009). Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorganic and Medicinal Chemistry Letters, 19(6), 1784-1789. https://doi.org/10.1016/j.bmcl.2009.01.069