Salicylate-induced pulmonary edema: Clinical characteristics in children

Charles J. Fisher, Timothy E Albertson, Garrett E. Foulke

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A five-year retrospective study of pediatric salicylate intoxications (serum level >300 μg/ml) revealed that 2 20 patients developed salicylate induced pulmonary edema. These patients had significantly higher initial anion gaps (P < 0.02) and serum salicylate determinations (P < 0.001) and tended to be younger with lower initial serum potassium and arterial carbon dioxide measurements. Both patients in the salicylate-induced pulmonary edema group died, whereas none in the non-pulmonary edema group died. Unlike other reports, these data suggest that pulmonary edema is not rare in severe pediatric salicylate ingestion and correlates with high serum salicylate levels and anion gaps. Early, aggressive detoxification, supportive therapy, and hemodynamic monitoring would appear to be indicated in these patients.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalAmerican Journal of Emergency Medicine
Issue number1
StatePublished - 1985


  • Aspirin
  • drug-induced pulmonary edema
  • intoxication
  • pediatric overdoses
  • poisoning
  • pulmonary edema
  • salicylate

ASJC Scopus subject areas

  • Emergency Medicine


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