Safety of cupping during bevacizumab therapy

Samuel J. Klempner, Daniel B. Costa, Peggy Wu, Kim D. Ariyabuddhiphongs

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objectives: This study reports on the safety of the complementary and alternative medicine (CAM) practice of cupping in a patient undergoing concomitant therapy with bevacizumab for advanced non-small-cell lung cancer (NSCLC), and raises awareness of the need for improved communication between CAM practitioners and oncologists during the care of patients with cancer. The practice of cupping generates local hyperemia, disrupts superficial vasculature in the dermis, and leads to cutaneous lesions including circular erythema, edema, and subsequently ecchymosis. There are no data on the safety of cupping in patients being treated with bevacizumab. Design: This is a single-institution case report. Settings/location: The setting for this study was a tertiary-care academic medical center. Conclusions: A patient with advanced NSCLC received four cycles of carboplatin AUC 6, paclitaxel 200 mg/m2, and bevacizumab 15 mg/kg, and was continued on every-3-week maintenance bevacizumab 15 mg/kg. The patient underwent glass dry cupping during cycle six of maintenance bevacizumab treatment without overt cutaneous adverse events or bleeding. The patient did not realize he should have communicated his cupping plans or recent bevacizumab treatment with his providers.

Original languageEnglish (US)
Pages (from-to)729-731
Number of pages3
JournalJournal of Alternative and Complementary Medicine
Issue number8
StatePublished - Aug 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Complementary and alternative medicine


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