Abstract
Objective: Long-term access to the fetal circulation has the potential to open up new perspectives in the treatment of numerous fetal anomalies. The purpose of this study was to investigate the safety of long-term catheterization of fetal placental vessels. Methods: A midline laparotomy was performed in 4 time-mated pregnant ewes at 125 days' gestation (term 145 days). Placental vessels were exposed by a small uterine incision. A specially designed catheter was inserted into a placental vessel over a length of 3 cm, the distal end of the catheter was tunneled underneath the maternal skin and attached to a subcutaneous port implanted in the maternal flank. All pregnancies were allowed to go to term. Results: Ewes and fetuses tolerated the placement of the catheter and port without complications. The catheter remained patent in all cases. All lambs were delivered vaginally at term and did not require resuscitation after birth. No fetal anomalies or growth restriction were noted. Conclusion: The ovine placental vessel can be accessed long term without complication.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 98-100 |
| Number of pages | 3 |
| Journal | Fetal Diagnosis and Therapy |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Fetal diagnosis
- Fetal therapy
- Fetal vascular access
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Pediatrics, Perinatology, and Child Health
Cite this
Safety of chronic fetal vascular access in the sheep model. / Paek, Bettina W.; Lopoo, John B.; Jennings, Russell W.; Farmer, Diana L; Albanese, Craig T.; Harrison, Michael R.
In: Fetal Diagnosis and Therapy, Vol. 16, No. 2, 2001, p. 98-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Safety of chronic fetal vascular access in the sheep model
AU - Paek, Bettina W.
AU - Lopoo, John B.
AU - Jennings, Russell W.
AU - Farmer, Diana L
AU - Albanese, Craig T.
AU - Harrison, Michael R.
PY - 2001
Y1 - 2001
N2 - Objective: Long-term access to the fetal circulation has the potential to open up new perspectives in the treatment of numerous fetal anomalies. The purpose of this study was to investigate the safety of long-term catheterization of fetal placental vessels. Methods: A midline laparotomy was performed in 4 time-mated pregnant ewes at 125 days' gestation (term 145 days). Placental vessels were exposed by a small uterine incision. A specially designed catheter was inserted into a placental vessel over a length of 3 cm, the distal end of the catheter was tunneled underneath the maternal skin and attached to a subcutaneous port implanted in the maternal flank. All pregnancies were allowed to go to term. Results: Ewes and fetuses tolerated the placement of the catheter and port without complications. The catheter remained patent in all cases. All lambs were delivered vaginally at term and did not require resuscitation after birth. No fetal anomalies or growth restriction were noted. Conclusion: The ovine placental vessel can be accessed long term without complication.
AB - Objective: Long-term access to the fetal circulation has the potential to open up new perspectives in the treatment of numerous fetal anomalies. The purpose of this study was to investigate the safety of long-term catheterization of fetal placental vessels. Methods: A midline laparotomy was performed in 4 time-mated pregnant ewes at 125 days' gestation (term 145 days). Placental vessels were exposed by a small uterine incision. A specially designed catheter was inserted into a placental vessel over a length of 3 cm, the distal end of the catheter was tunneled underneath the maternal skin and attached to a subcutaneous port implanted in the maternal flank. All pregnancies were allowed to go to term. Results: Ewes and fetuses tolerated the placement of the catheter and port without complications. The catheter remained patent in all cases. All lambs were delivered vaginally at term and did not require resuscitation after birth. No fetal anomalies or growth restriction were noted. Conclusion: The ovine placental vessel can be accessed long term without complication.
KW - Fetal diagnosis
KW - Fetal therapy
KW - Fetal vascular access
UR - http://www.scopus.com/inward/record.url?scp=0035104843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035104843&partnerID=8YFLogxK
U2 - 10.1159/000053889
DO - 10.1159/000053889
M3 - Article
C2 - 11173956
AN - SCOPUS:0035104843
VL - 16
SP - 98
EP - 100
JO - Fetal Diagnosis and Therapy
JF - Fetal Diagnosis and Therapy
SN - 1015-3837
IS - 2
ER -