Safety and immunogenicity of a polyvalent peptide C4-V3 HIV vaccine in conjunction with IL-12

Beverly E. Sha, Michelle Onorato, John A. Bartlett, Ronald J. Bosch, Evgenia Aga, Mostafa Nokta, Elizabeth M. Adams, Xiao Dong Li, John Eldridge, Richard B Pollard

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We examined the safety and immunogenicity of a human leukocyte antigen-based HIV envelope polyvalent synthetic peptide vaccine, C4-V3, alone and in combination with subcutaneous IL-12 in nine HIV-infected patients. Lymphocyte proliferative responses increased threefold or more to all four peptides at two consecutive post-immunization timepoints for four individuals. Three responders had received IL-12, suggesting a possible adjuvant effect of IL-12. Transient mild injection site reactions (7/9) and systemic symptoms (3/9) occurred.

Original languageEnglish (US)
Pages (from-to)1203-1206
Number of pages4
JournalAIDS
Volume18
Issue number8
DOIs
StatePublished - May 21 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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