Safety and efficacy of probiotic administration to preterm infants: ten common questions

Mark A. Underwood, Erin Umberger, Ravi M. Patel

Research output: Contribution to journalArticlepeer-review

Abstract

In spite of a large number of randomized placebo-controlled clinical trials and observational cohort studies including >50,000 preterm infants from 29 countries that have demonstrated a decrease in the risk of necrotizing enterocolitis, death, and sepsis, routine prophylactic probiotic administration to preterm infants remains uncommon in much of the world. This manuscript reflects talks given at NEC Society Symposium in 2019 and is not intended to be a state-of-the-art review or systematic review, but a summary of the probiotic-specific aspects of the symposium with limited additions including a recent strain-specific network analysis and position statement from the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN). We address ten common questions related to the intestinal microbiome and probiotic administration to the preterm infant.

Original languageEnglish (US)
Pages (from-to)48-55
Number of pages8
JournalPediatric research
Volume88
DOIs
StatePublished - Aug 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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