Abstract
Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.
Original language | English (US) |
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Pages (from-to) | 941-945 |
Number of pages | 5 |
Journal | Pest Management Science |
Volume | 57 |
Issue number | 10 |
DOIs | |
State | Published - 2001 |
Keywords
- Ca transport
- Ryanodine receptor
- Sulfhydryl
ASJC Scopus subject areas
- Agronomy and Crop Science
- Insect Science