Ryanodine receptor acts as a sensor for redox stress

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalPest Management Science
Volume57
Issue number10
DOIs
StatePublished - 2001

Fingerprint

ryanodine receptors
calcium
insect control
xenobiotics
chemistry
insecticides
pesticides
pollution

Keywords

  • Ca transport
  • Ryanodine receptor
  • Sulfhydryl

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Insect Science

Cite this

Ryanodine receptor acts as a sensor for redox stress. / Pessah, Isaac N.

In: Pest Management Science, Vol. 57, No. 10, 2001, p. 941-945.

Research output: Contribution to journalArticle

@article{fb430aec264541c4bd78c65b9db9ab14,
title = "Ryanodine receptor acts as a sensor for redox stress",
abstract = "Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.",
keywords = "Ca transport, Ryanodine receptor, Sulfhydryl",
author = "Pessah, {Isaac N}",
year = "2001",
doi = "10.1002/ps.391",
language = "English (US)",
volume = "57",
pages = "941--945",
journal = "Pest Management Science",
issn = "1526-498X",
publisher = "John Wiley and Sons Ltd",
number = "10",

}

TY - JOUR

T1 - Ryanodine receptor acts as a sensor for redox stress

AU - Pessah, Isaac N

PY - 2001

Y1 - 2001

N2 - Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.

AB - Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.

KW - Ca transport

KW - Ryanodine receptor

KW - Sulfhydryl

UR - http://www.scopus.com/inward/record.url?scp=0034769063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034769063&partnerID=8YFLogxK

U2 - 10.1002/ps.391

DO - 10.1002/ps.391

M3 - Article

C2 - 11695187

AN - SCOPUS:0034769063

VL - 57

SP - 941

EP - 945

JO - Pest Management Science

JF - Pest Management Science

SN - 1526-498X

IS - 10

ER -