Ryanodine receptor acts as a sensor for redox stress

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalPest Management Science
Volume57
Issue number10
DOIs
StatePublished - 2001

Keywords

  • Ca transport
  • Ryanodine receptor
  • Sulfhydryl

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Insect Science

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