Abstract
Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 941-945 |
| Number of pages | 5 |
| Journal | Pest Management Science |
| Volume | 57 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Ca transport
- Ryanodine receptor
- Sulfhydryl
ASJC Scopus subject areas
- Agronomy and Crop Science
- Insect Science
Cite this
Ryanodine receptor acts as a sensor for redox stress. / Pessah, Isaac N.
In: Pest Management Science, Vol. 57, No. 10, 2001, p. 941-945.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ryanodine receptor acts as a sensor for redox stress
AU - Pessah, Isaac N
PY - 2001
Y1 - 2001
N2 - Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.
AB - Ryanoids have not attained importance as insecticides, but the increasing number of xenobiotic effectors known to influence Ca2+ signalling by interaction with ryanodine receptors (RyRs) may serve to identify new targets for insect control. A historical review of redox control of microsomal Ca2+ transport is given here, followed by recent evidence indicating that hyperactive Cys residues are an essential component of a transmembrane redox sensor. Focus is on the role of sulfhydryl chemistry in RyR regulation; metabolic quinonoid intermediates from pesticides and other environmental contaminants are of interest in this context.
KW - Ca transport
KW - Ryanodine receptor
KW - Sulfhydryl
UR - http://www.scopus.com/inward/record.url?scp=0034769063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034769063&partnerID=8YFLogxK
U2 - 10.1002/ps.391
DO - 10.1002/ps.391
M3 - Article
C2 - 11695187
AN - SCOPUS:0034769063
VL - 57
SP - 941
EP - 945
JO - Pest Management Science
JF - Pest Management Science
SN - 1526-498X
IS - 10
ER -